INT131574

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) endosome (Ephb1) mitochondrion (Creb1)
DNA binding (Creb1) cytoplasm (Ephb1) signal transduction (Ephb1)
Anatomy Link Frequency
spinal 3
Ephb1 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 9 100.00 Very High Very High Very High
Morphine 7 100.00 Very High Very High Very High
Spinal cord 2 99.48 Very High Very High Very High
allodynia 1 96.44 Very High Very High Very High
intrathecal 2 92.56 High High
nMDA receptor 1 91.60 High High
antagonist 1 89.20 High High
Kinase C inhibitor 1 87.52 High High
narcan 4 84.48 Quite High
psychological dependence 1 77.56 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 96.44 Very High Very High Very High
Drug Dependence 2 77.56 Quite High
Substance Withdrawal Syndrome 1 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spinal ERK inhibition or knockdown also reduced morphine withdrawal-induced phosphorylation of cAMP response element binding protein (CREB), which is one of the important downstream substrates of ERK pathway, and Fos expression.
Negative_regulation (inhibition) of ERK in spinal Negative_regulation (reduced) of Gene_expression (expression) of cAMP response element binding protein in spinal associated with withdrawal and morphine
1) Confidence 0.41 Published 2005 Journal Pain Section Abstract Doc Link 16289800 Disease Relevance 0.33 Pain Relevance 1.58

General Comments

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