INT131632

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
trigeminal ganglion 2
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 4 98.18 Very High Very High Very High
Neuropathic pain 2 97.44 Very High Very High Very High
Trigeminal ganglion neurons 1 96.38 Very High Very High Very High
fifth nerve 2 77.12 Quite High
trigeminal ganglion 2 75.00 Quite High
Analgesic 1 53.12 Quite High
Face pain 1 44.40 Quite Low
Hyperesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 97.44 Very High Very High Very High
Ganglion Cysts 3 96.22 Very High Very High Very High
Injury 3 78.24 Quite High
Hypersensitivity 3 77.64 Quite High
Nervous System Injury 1 61.12 Quite High
Facial Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Investigations of gene expression changes in injured trigeminal ganglion neurons of animals with behavioral signs of neuropathic pain demonstrated that the sodium channel alpha-subunit Na(v)1.3-absent in sham-operated animals-was expressed to a limited extent. mRNAs for Na(v)1.8 and Na(v)1.9 were reduced both with respect to proportions of expressing neurons and to intensities, whereas the beta 3 subunit was markedly upregulated. mRNA levels of p11, a regulatory factor that facilitates the surface expression of Na(v)1.8, were unchanged.
Negative_regulation (reduced) of Positive_regulation (mRNAs) of Na(v)1.8 in trigeminal ganglion associated with ganglion cysts, sodium channel, neuropathic pain and trigeminal ganglion neurons
1) Confidence 0.41 Published 2005 Journal Pain Section Abstract Doc Link 16297558 Disease Relevance 0.89 Pain Relevance 0.53

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