INT131851

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2006
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 17
Disease Relevance 9.44
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RHOC) signal transduction (RHOC) plasma membrane (RHOC)
nucleus (RHOC) intracellular (RHOC) GTPase activity (RHOC)
Anatomy Link Frequency
HPAF-II 3
PC-3 2
arm 1
BxPC-3 1
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Intractable pain 2 82.92 Quite High
Spinal cord 2 81.92 Quite High
Chronic pancreatitis 30 69.88 Quite High
Inflammation 30 58.08 Quite High
fibrosis 15 21.36 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 765 99.84 Very High Very High Very High
Reprotox - General 1 2 99.60 Very High Very High Very High
Cancer 467 99.18 Very High Very High Very High
Metastasis 355 97.46 Very High Very High Very High
Carcinoma 17 94.28 High High
Pancreatic Cancer 105 93.56 High High
Recurrence 2 88.40 High High
Intractable Pain 2 82.92 Quite High
Spinal Cord Compression 2 82.40 Quite High
Bone Fracture 2 82.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, interaction of cav-1 and RhoC may result in decreased RhoC activation, limiting cell migration and invasion.


Positive_regulation (activation) of RhoC
1) Confidence 0.57 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.10 Pain Relevance 0
Rho activation assay reagents were supplied to us by John Collard, Ph.D. at the Netherlands Cancer Institute [56,57] and used to determine activation of RhoC in PC cells.
Spec (determine) Positive_regulation (activation) of RhoC associated with adenocarcinoma and cancer
2) Confidence 0.57 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.20 Pain Relevance 0
In the current study, we demonstrate that RhoC GTPase is expressed and active in PC-3 CaP cells.
Positive_regulation (active) of RhoC in PC-3
3) Confidence 0.46 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.12 Pain Relevance 0.12
RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility.
Positive_regulation (required) of RhoC in PC-3 associated with reprotox - general 1
4) Confidence 0.46 Published 2006 Journal Oncogene Section Title Doc Link 16314838 Disease Relevance 1.05 Pain Relevance 0.12
Increased cellular migration was accompanied by a significant increase in active GTP-bound RhoC (Figure 6B; p = 0.0001).
Positive_regulation (increase) of RhoC
5) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.27 Pain Relevance 0
High cav-1 protein expression leads to inhibition of RhoC activation while inhibition of RhoC activity leads to partial re-expression of cav-1.
Positive_regulation (activation) of RhoC
6) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.08 Pain Relevance 0
These data further suggest that activation of RhoC GTPase is regulated by cav-1 and that RhoC signals through the p38 arm of the MAPK pathway to induce cellular migration.


Positive_regulation (activation) of RhoC in arm
7) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.36 Pain Relevance 0
Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.
Neg (without) Positive_regulation (effecting) of RhoC protein
8) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.31 Pain Relevance 0
Figure 2B is a comparison of RhoC expression and activation in the BxPC-3 and HPAF-II cell lines.
Positive_regulation (activation) of RhoC in HPAF-II
9) Confidence 0.38 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.42 Pain Relevance 0
This study suggests that cav-1 expression suppresses RhoC GTPase activation and RhoC-mediated cellular migration and invasion.
Positive_regulation (activation) of RhoC
10) Confidence 0.38 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.63 Pain Relevance 0.03
Loss of cav-1 expression leads to increased RhoC activation favoring the p38 MAPK pathway and cellular migration and invasion.
Positive_regulation (activation) of RhoC
11) Confidence 0.38 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.73 Pain Relevance 0
To determine if cav-1 expression affected RhoC activation, levels of GTP-bound RhoC was measured in the GFP-cav-1 and control HPAF-II cells (Figure 2C).
Positive_regulation (activation) of RhoC in HPAF-II
12) Confidence 0.38 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.37 Pain Relevance 0
Comparison of the BxPC-3 (derived from a primary tumor) and HPAF-II (derived from a metastasis) demonstrates a reciprocal relationship between cav-1 expression and p42/p44 Erk activation with PC cell migration, invasion, RhoC GTPase and p38 MAPK activation.
Positive_regulation (activation) of RhoC in HPAF-II associated with adenocarcinoma, cancer and metastasis
13) Confidence 0.38 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1173138 Disease Relevance 1.06 Pain Relevance 0
Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.
Positive_regulation (activation) of RhoC
14) Confidence 0.38 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.21 Pain Relevance 0
Cav-1 expression inhibits RhoC GTPase activation and subsequent activation of the p38 MAPK pathway in primary PC cells thus restricting migration and invasion.
Positive_regulation (activation) of RhoC associated with adenocarcinoma
15) Confidence 0.38 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1173138 Disease Relevance 0.94 Pain Relevance 0
In the present study we demonstrate that cav-1 expression in PC cell lines regulates RhoC activation and cellular migration and invasion through the mitogen activated protein kinase (MAPK) pathway.


Positive_regulation (activation) of RhoC associated with adenocarcinoma
16) Confidence 0.38 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.19 Pain Relevance 0.13
Figure 2B is a comparison of RhoC expression and activation in the BxPC-3 and HPAF-II cell lines.
Positive_regulation (activation) of RhoC in BxPC-3
17) Confidence 0.13 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.42 Pain Relevance 0

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