INT132283

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Context Info
Confidence 0.13
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
Lamina 1
P2rx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 20 99.70 Very High Very High Very High
Potency 27 87.44 High High
Dorsal horn neuron 6 86.20 High High
Spinal cord 19 85.52 High High
Glutamate receptor 1 85.00 Quite High
narcan 2 83.36 Quite High
Glutamate 3 83.24 Quite High
opioid receptor 1 82.56 Quite High
primary afferent fibers 8 81.80 Quite High
guanethidine 2 81.28 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 48.68 Quite Low
Reprotox - General 1 1 39.52 Quite Low
Nociception 16 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Coagulation Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The P2X4 receptor mutants Lys190Ala and Phe230Ala were essentially insensitive to ATP (Yan et al., 2005), while the equivalent alanine mutants had little or no effect at P2X1 receptors (Ennion et al., 2000; Roberts and Evans, 2004).
Neg (little) Regulation (effect) of P2X1
1) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.22
The contractile effect of alpha,beta-meATP (3 microM) was moderately inhibited by 10 microM and strongly suppressed by 30 microM of NF 279, an antagonist predominantly affecting P2X1 purinoceptors, but left uninfluenced by the P2X(5,7) receptor antagonist Brilliant blue G.
Regulation (affecting) of P2X1 associated with antagonist
2) Confidence 0.10 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16364052 Disease Relevance 0 Pain Relevance 0.51
Lamina distribution of afferent fibers that express other P2X subunits remains unclear, although there was a report that showed immunoreactivity of P2X1 and P2X2 subunits in superfacial lamina as well [50].
Regulation (immunoreactivity) of P2X1 in Lamina
3) Confidence 0.06 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096570 Disease Relevance 0 Pain Relevance 0.47

General Comments

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