INT132477

Context Info Confidence 0.45 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.24 Pain Relevance 0.05

small molecule metabolic process (TSHB) extracellular region (TSHB) cellular nitrogen compound metabolic process (TSHB) cell-cell signaling (TSHB)

Anatomy Link Frequency thyroid 4 TSHB (Homo sapiens)

Pain Link Frequency Relevance Heat depression 24 90.92 biopsychosocial 7 50.00 withdrawal 7 5.00 beta blocker 4 5.00 Inflammation 3 5.00 Pain 3 5.00 Analgesic 2 5.00 alcohol 2 5.00 tolerance 2 5.00 iatrogenic 1 5.00

Disease Link Frequency Relevance Heat Hypothyroidism 35 99.10 Cancer 15 99.04 Thyroid Neoplasm 95 98.46 Disease 36 94.12 Constipation 1 94.12 Heart Rate Under Development 2 93.56 Hoarseness 1 92.64 Weight Gain 14 92.16 Thyroiditis 2 91.60 Depression 26 90.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Serum hormonal assay indicated a decrease in testosterone and follicular stimulating hormone levels in treated rats.

Negative_regulation (decrease) of stimulating hormone

1) Confidence 0.45 Published 2005 Journal Neuro Endocrinol. Lett. Section Body Doc Link 16380694 Disease Relevance 0 Pain Relevance 0

The reasons for impaired quality of life in thyroid cancer survivors in whom the cancer has been cured are not well-understood are not related to thyroid stimulating hormone (TSH) levels [27].

Neg (not) Negative_regulation (related) of thyroid stimulating hormone in thyroid associated with thyroid neoplasm and cancer

2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615133 Disease Relevance 1.25 Pain Relevance 0

In particular, six consecutive nights of sleep restriction (four hours sleep per night) were associated with increases in sympathetic nervous system (SNS) activity, evening cortisol levels and growth hormone levels (GH), and reductions in thyroid stimulating hormone (TSH), and leptin [16, 17, 41].

Negative_regulation (reductions) of thyroid stimulating hormone in thyroid

3) Confidence 0.13 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.27 Pain Relevance 0

Serum levels of thyroid stimulating hormone (TSH) and total thyroxine (T4) were only available for 2,299 participants ?

Negative_regulation (levels) of thyroid stimulating hormone in thyroid

4) Confidence 0.08 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764147 Disease Relevance 0 Pain Relevance 0

Laboratory testing in individuals with primary overt hypothyroidism typically depicts an elevated serum thyroid stimulating hormone (TSH) level, and a decrease in serum free-thyroxine (FT4) levels [3].

Negative_regulation (decrease) of stimulating hormone in thyroid associated with hypothyroidism

5) Confidence 0.06 Published 2010 Journal Trials Section Body Doc Link PMC2992059 Disease Relevance 1.71 Pain Relevance 0.05

General Comments

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