INT132492

Context Info Confidence 0.56 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.11 Pain Relevance 0.17

endoplasmic reticulum (UGT2B15)

Anatomy Link Frequency 2B7 2 UGT2B15 (Homo sapiens)

Pain Link Frequency Relevance Heat Endep 6 93.80 Morphine 2 37.04 cINOD 4 5.00 diclofenac 1 5.00 Pain 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Injury 8 56.08 Obesity 11 55.08 Renal Disease 18 50.00 Hepatotoxicity 1 25.88 Acute Renal Failure 1 23.72 Renal Failure 2 15.56 Membranoproliferative Glomerulonephritis 1 14.64 Focal Segmental Glomerulosclerosis 5 5.00 Chronic Renal Failure 4 5.00 Pulmonary Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

UGT2B17 catalyses glucuronidation at both oxygens whereas UGT2B15 acts only at the 17 ?

Gene_expression (acts) of UGT2B15

1) Confidence 0.56 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.11 Pain Relevance 0

Selectivity was assessed using UGTs 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B7, and 2B15 expressed in HEK293 cells.

Gene_expression (expressed) of 2B15 in 2B7

2) Confidence 0.26 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16381668 Disease Relevance 0 Pain Relevance 0.08

Selectivity was assessed using UGTs 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B7, and 2B15 expressed in HEK293 cells.

Gene_expression (using) of 2B15 in 2B7

3) Confidence 0.23 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16381668 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.