INT132533

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3r2) signal transduction (Pik3r2) intracellular (Pik3r2)
kinase activity (Pik3r2)
Anatomy Link Frequency
brainstem 2
Pik3r2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 4 99.46 Very High Very High Very High
medulla 1 96.96 Very High Very High Very High
opiate 3 93.32 High High
Ventral tegmentum 1 77.84 Quite High
opioid receptor 2 75.00 Quite High
amygdala 1 73.52 Quite High
Locus ceruleus 3 41.36 Quite Low
Morphine 1 29.28 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Attenuated expression of withdrawal behaviors correlated with decreased c-Fos expression and intracellular signal transduction elements [protein kinase A regulatory subunit II (PKA) and phosphorylated cAMP response element binding protein (pCREB)] in brainstem noradrenergic nuclei.
Negative_regulation (decreased) of Gene_expression (expression) of regulatory subunit II in brainstem associated with medulla and withdrawal
1) Confidence 0.03 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.08 Pain Relevance 0.56

General Comments

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