INT132682

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.61
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
dorsal 2
RVM 1
neurons 1
Dorsal root ganglion 1
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 158 100.00 Very High Very High Very High
opioid receptor 111 100.00 Very High Very High Very High
Delta opioid receptors 21 100.00 Very High Very High Very High
Central grey 15 100.00 Very High Very High Very High
Periaqueductal grey 13 100.00 Very High Very High Very High
tolerance 56 99.96 Very High Very High Very High
Rostral ventromedial medulla 7 99.84 Very High Very High Very High
Spinal cord 21 99.60 Very High Very High Very High
Inflammation 11 98.48 Very High Very High Very High
Dopamine 2 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 67 100.00 Very High Very High Very High
INFLAMMATION 12 98.48 Very High Very High Very High
Nociception 46 98.12 Very High Very High Very High
Pain 45 96.60 Very High Very High Very High
Stress 6 96.00 Very High Very High Very High
Pressure Volume 2 Under Development 4 94.72 High High
Anxiety Disorder 11 91.32 High High
Inflammatory Pain 12 89.12 High High
Hemorrhage 2 85.40 High High
Ganglion Cysts 1 83.74 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study evaluated the effect of unilateral or bilateral lesion of dorsal portion of PAG (dPAG: dorsolateral and dorsomedial columns) (i) on nociceptive response induced by 2.5% formalin injection into the right hind paw (nociception test) in mice exposed to a non-aversive situation or to the oEPM and (ii) on anxiety indices in mice exposed to a standard elevated plus-maze (sEPM: two open and two closed arms) with or without prior injection of 2.5% formalin.
Phosphorylation (portion) of PAG in dorsal associated with nociception, anxiety disorder and central grey
1) Confidence 0.71 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19410607 Disease Relevance 1.10 Pain Relevance 0.53
The present study evaluated the effect of unilateral or bilateral lesion of dorsal portion of PAG (dPAG: dorsolateral and dorsomedial columns) (i) on nociceptive response induced by 2.5% formalin injection into the right hind paw (nociception test) in mice exposed to a non-aversive situation or to the oEPM and (ii) on anxiety indices in mice exposed to a standard elevated plus-maze (sEPM: two open and two closed arms) with or without prior injection of 2.5% formalin.
Phosphorylation (portion) of dPAG in dorsal associated with nociception, anxiety disorder and central grey
2) Confidence 0.71 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19410607 Disease Relevance 1.10 Pain Relevance 0.53
PAG DORs could contribute to morphine tolerance [38–40], behavioral changes
Phosphorylation (morphine) of PAG associated with tolerance, urological neuroanatomy, delta opioid receptors and morphine
3) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 1.20 Pain Relevance 0.98
In contrast to morphine, the initial dose of DAMGO stimulated strong Ser375 phosphorylation and internalization of MORs in PAG neurons.
Phosphorylation (phosphorylation) of PAG in neurons associated with urological neuroanatomy, opioid receptor and morphine
4) Confidence 0.22 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.10 Pain Relevance 1.24
2-AG: 2-arachidonoyl glycerol; 2-EGs: 2-epoxyeicosatrienoyl-glycerols; AA-5HT: N-arachidonoyl serotonin; AEA: N-arachidonoyl ethanolaminem, Anandamide; cAMP: cyclic adenosine monophosphate; CB1: Cannabinoid 1 receptor; CB2: Cannabinoid 2 receptor; CCI: Chronic constriction injury; CFA: Complete Freunds adjuvant; COX-2: Cylcooxygenase type 2; CYP450: Cytochrome P450; DAG(L): Diacylglycerol (Lipase); DHETE-G: Dihydroxyeicosatrienoic acid glycerol ester; DR: Dorsal Raphe Nucleus; DRG: Dorsal root ganglion; EET-EA: Epoxyeicosatrienoic acid ethanolamide; FAAH: Fatty acid amide hydrolase; GpAEA: glycerophospho-N-arachidonoyl ethanolamine; GpOEA: glycerophospho-N-oleoyl ethanolamine; GpPEA: glycerophospho-N-palmitoyl ethanolamine; GpNAE - glycerophospho-N-acyl ethanolamine; HETE: Hydroxyeicosatetraenoic acid; HPETE-G: Hydroxyperoxyeicosa-5,8,10,14-tetraenoic acid glycerol ester; i.p.: Intraperitoneal administration; i.pl.: Intraplantar administration; LOX: Lipoxygenase; LPS: Lipopolysaccharide; MAGL: Monoacylglycerol lipase; MAPK: Mitogen activated protein kinase; NAAA: N-acylethanolamine hydrolysing acid amidase; NADA: N-arachidonoyl dopamine; NAE: N-acylethanolamines; NAPE: N-phosphatidyl ethanolamine; NArPE: arachidonoyl containing NAPE; NMDA: N-methyl-D-aspartic acid; OEA: N-oleoyl ethanolamine; pAEA: phosphorylated anandamide; PAG: Periaqueductal grey; PEA: N-palmitoyl ethanolamine; PLA1: Phospholipase A1; PLC: Phospholipase C; PLD: Phospholipase D; p.o.: Oral administration; PPAR: Peroxisome proliferator-activated receptor; PGE2-G: Prostaglandin E2-glycerol; RVM: Rostrovental Medulla; SNL: Spinal nerve ligation; ?
Phosphorylation (phosphorylated) of PAG in Dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, dopamine, periaqueductal grey, eae, cannabinoid, medulla, adenocard, injury, 5ht, serotonin and raphe
5) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.44 Pain Relevance 0.59
A single oral administration of SJW produced a significant decrease of the PKCgamma (131.8+/-10.0) and PKCepsilon (105.2+/-12.0) phosphorylation in the PAG area due to the presence of hypericin.
Phosphorylation (phosphorylation) of PAG associated with periaqueductal grey
6) Confidence 0.04 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20045676 Disease Relevance 0.70 Pain Relevance 0.84
BDNF in PAG and TrkB phosphorylation in RVM neurons are upregulated after inflammation.
Phosphorylation (phosphorylation) of PAG in RVM associated with inflammation, central grey and rostral ventromedial medulla
7) Confidence 0.03 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399679 Disease Relevance 0.97 Pain Relevance 1.05

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