INT132759

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.12
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleus (Pgr) enzyme binding (Pgr)
DNA binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
lymph nodes 2
mammary glands 2
stromal cells 2
Pgr (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 2 97.56 Very High Very High Very High
endometriosis 11 88.40 High High
Inflammation 20 84.04 Quite High
cytokine 6 68.80 Quite High
Inflammatory marker 1 61.12 Quite High
pain pelvic 2 55.72 Quite High
Pain 2 51.16 Quite High
antagonist 3 37.76 Quite Low
Potency 1 36.88 Quite Low
Inflammatory mediators 3 35.92 Quite Low
Disease Link Frequency Relevance Heat
Cancer 110 100.00 Very High Very High Very High
Breast Cancer 44 98.72 Very High Very High Very High
Carcinoma 30 98.00 Very High Very High Very High
Endometriosis 13 98.00 Very High Very High Very High
Targeted Disruption 32 97.40 Very High Very High Very High
Sprains And Strains 188 96.60 Very High Very High Very High
Disease 5 96.52 Very High Very High Very High
Reprotox - General 1 5 96.20 Very High Very High Very High
Hyperplasia 12 96.12 Very High Very High Very High
Premature Birth 54 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
overexpression, increased PR levels were also observed.
Positive_regulation (increased) of Gene_expression (levels) of PR
1) Confidence 0.38 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.65 Pain Relevance 0
In addition, virgin BALB/c mammary glands expressed higher levels of PR-A and ER-?
Positive_regulation (levels) of Gene_expression (expressed) of PR in mammary glands
2) Confidence 0.38 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.34 Pain Relevance 0
overexpression, increased PR levels were also observed.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PR
3) Confidence 0.38 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.65 Pain Relevance 0
overexpression, increased PR levels were also observed.
Positive_regulation (increased) of Gene_expression (overexpression) of PR
4) Confidence 0.38 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.65 Pain Relevance 0
Binding of progesterone to PR-A, the short form of the receptor, not thought to be associated with intra-cellular pathway mechanisms, prevents the actions of progesterone mediated by PR-B.71 An increase in the myometrial PR-A to PR-B expression ratio occurs at the onset of labor at term, resulting in an increase in myometrial PR-A, and in effect a functional withdrawal of progesterone,71,72 with increasing sensitivity to contractile stimuli.65,67,73,74 Prostaglandins produced prior to the onset of labor, also act to increase the PR-A/PR-B expression ratio, and therefore the potential to initiate a functional withdrawal of progesterone.67 In many animals the onset of labor is associated with a decrease in progesterone concentrations,62,64,65,75 but this has not been shown to occur in women before term or preterm birth, with no apparently detectable changes to circulating steroid hormone levels evident.64,65,67,76,77

Progesterone as an anti-inflammatory agent

Positive_regulation (increase) of Gene_expression (expression) of PR-B associated with inflammation, premature birth and withdrawal
5) Confidence 0.26 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971700 Disease Relevance 0.47 Pain Relevance 0.19
The inability of endometriotic stromal cells to produce progesterone-induced paracrine factors that stimulate 17beta-HSD-2 may be due to the lack of PR-B and very low levels of progesterone receptor A (PR-A) observed in vivo in endometriotic tissue.
Positive_regulation (due) of Neg (lack) Gene_expression (lack) of PR-B in stromal cells associated with endometriosis
6) Confidence 0.07 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 0.92 Pain Relevance 0.41
In breast cancer, two small retrospective studies has shown an association with elevated clusterin expression and large tumor size, estrogen and progesterone receptor status and with the progression from the primary carcinoma to metastatic carcinoma in lymph nodes in breast cancer [32,33].
Positive_regulation (elevated) of Gene_expression (expression) of progesterone receptor in lymph nodes associated with cancer, breast cancer and carcinoma
7) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 1.30 Pain Relevance 0.03
Ulipristal acetate, also referred to as CDB-2914 or VA2914, is a novel orally active selective progesterone receptor modulator (SPRM) with the chemical name 17?
Positive_regulation (selective) of Gene_expression (modulator) of progesterone receptor
8) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0.08 Pain Relevance 0
PR-A, PR-B, AR, and FasL expression were all increased as compared with untreated cells.
Positive_regulation (increased) of Gene_expression (expression) of PR-B
9) Confidence 0.03 Published 2006 Journal Gynecol. Obstet. Invest. Section Body Doc Link 16778450 Disease Relevance 0.06 Pain Relevance 0

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