INT132863

Context Info Confidence 0.23 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.11 Pain Relevance 0.43

extracellular region (Ngf, Bdnf) signal transduction (Ngf) extracellular space (Ngf) aging (Ngf) cytoplasmic membrane-bounded vesicle (Bdnf) molecular_function (Ngf)

Ngf (Rattus norvegicus) Bdnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 2 98.86 IPN 1 96.16 Nerve growth factor 1 94.16 depression 1 78.96 Peripheral nervous system 2 73.48 agonist 1 47.04 antagonist 1 46.32

Disease Link Frequency Relevance Heat Asthma 3 99.08 Pain 2 98.86 Disease 6 97.68 Inflammatory Pain 1 96.16 Depression 1 78.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both pain and asthma show an underlying pathophysiology linked to increases in endogenous NGF and subsequent NGF-dependent increase in BDNF.

Positive_regulation (increases) of NGF Positive_regulation (increase) of BDNF associated with asthma and pain

1) Confidence 0.23 Published 2006 Journal Clin. Sci. Section Abstract Doc Link 16411894 Disease Relevance 1.11 Pain Relevance 0.43

General Comments

This test has worked.