INT13287

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Context Info
Confidence 0.56
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 7.84
Pain Relevance 11.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb2) extracellular space (Cpb2) extracellular region (Cpb2)
Anatomy Link Frequency
CPu 8
hippocampus 2
plasma 1
AcbS 1
brainstem 1
Cpb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 71 100.00 Very High Very High Very High
Nucleus accumbens 10 100.00 Very High Very High Very High
Ventral tegmentum 6 100.00 Very High Very High Very High
Substantia nigra 5 100.00 Very High Very High Very High
medulla 3 100.00 Very High Very High Very High
opioid receptor 31 99.98 Very High Very High Very High
Morphine 17 99.70 Very High Very High Very High
Hippocampus 19 99.68 Very High Very High Very High
agonist 30 99.46 Very High Very High Very High
Raphe 10 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 31 100.00 Very High Very High Very High
Coronary Artery Disease 14 99.84 Very High Very High Very High
Pain 23 97.88 Very High Very High Very High
Ischemic Heart Disease 3 96.84 Very High Very High Very High
Angina 114 96.72 Very High Very High Very High
Nociception 5 95.72 Very High Very High Very High
Stroke 72 95.36 Very High Very High Very High
Cv General 3 Under Development 6 95.04 Very High Very High Very High
Cv General 2 Under Development 3 93.16 High High
Myocardial Infarction 118 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mean cost per patient for all patients who attended a hospital with no CPU (i.e. all patients at control hospitals and pre-intervention patients at CPU hospitals) was £2405 (95% CI 2280 to 2529).
Gene_expression (hospitals) of CPU
1) Confidence 0.56 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2527313 Disease Relevance 0.14 Pain Relevance 0
Mean cost per patient was £2468 before and £2326 after intervention at the CPU hospitals, and was £2417 before and £2330 after intervention at the control hospitals.
Gene_expression (hospitals) of CPU
2) Confidence 0.56 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2527313 Disease Relevance 0.15 Pain Relevance 0
The mean cost per patient for all patients who attended a hospital with no CPU (i.e. all patients at control hospitals and pre-intervention patients at CPU hospitals) was £2405 (95% CI 2280 to 2529).
Gene_expression (hospitals) of CPU
3) Confidence 0.56 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2527313 Disease Relevance 0.13 Pain Relevance 0
Our previous work has shown that microinjection of different doses of norepinephrine into the CPu produces opposing effects in the tail-flick latency (TFL) of rats.
Gene_expression (produces) of CPu in CPu associated with tail-flick
4) Confidence 0.54 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20553996 Disease Relevance 0.72 Pain Relevance 0.64
Morphine-induced c-Fos expression in the CPu has been shown to be blocked by pretreatment with antagonists to N-methyl-D-aspartate receptors, indicating the involvement of glutamate in this morphine-induced response.
Gene_expression (expression) of CPu in CPu associated with glutamate, nmda receptor, antagonist and morphine
5) Confidence 0.49 Published 1999 Journal Brain Res. Section Abstract Doc Link 10446338 Disease Relevance 0 Pain Relevance 0.80
These data indicate that mu opioid receptor activation contributes to METH-induced gene expression in the CPu and stereotypy, and that patch-enhanced PD and arc expression may be a homeostatic response to METH treatment.
Gene_expression (expression) of CPu in CPu associated with aids-related complex and mu opioid receptor
6) Confidence 0.48 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20298714 Disease Relevance 0.41 Pain Relevance 0.20
Patch-enhanced PD and arc mRNA expression in the dorsolateral CPu correlated negatively with METH-induced stereotypy.
Gene_expression (expression) of CPu in CPu associated with aids-related complex
7) Confidence 0.48 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20298714 Disease Relevance 0.33 Pain Relevance 0.21
Conversely, SHR showed higher binding densities of delta receptors in 7 of 20 areas examined, including the CPu, CA2 and CA3 areas of the hippocampus and the central grey.
Gene_expression (areas) of CPu in central grey associated with hippocampus and central grey
8) Confidence 0.48 Published 1991 Journal Peptides Section Abstract Doc Link 1664945 Disease Relevance 0.31 Pain Relevance 0.65
Methamphetamine (METH) treatment also induces patch-enhanced expression of prodynorphin (PD), arc and zif/268 in the CPu.
Gene_expression (expression) of CPu in CPu associated with aids-related complex
9) Confidence 0.43 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20298714 Disease Relevance 0.17 Pain Relevance 0.14
A pronounced and time related decrease (25-65%) in prodynorphin gene expression was detected in AcbC, AcbS, CPu, hypothalamic supraoptic and paraventricular nuclei at all time points as well as in proopiomelanocortin gene expression (20-30%) in the arcuate nucleus (ARC) of the hypothalamus.
Gene_expression (detected) of CPu in AcbS associated with aids-related complex
10) Confidence 0.42 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15936043 Disease Relevance 0.09 Pain Relevance 0.95
Morphine significantly induced c-Fos expression in the dorsomedial CPu, as we have reported previously.
Gene_expression (expression) of CPu in CPu associated with morphine
11) Confidence 0.41 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838105 Disease Relevance 0 Pain Relevance 0.98
This study examined the effects of chronic, escalating doses of D-AMPH followed by 24 h of withdrawal on the expression of prodynorphin (PD) and c-fos mRNA in limbic regions of the brain, caudate putamen (CPu), and brainstem and SERT mRNA expression in the dorsal raphe nucleus (DRN).
Gene_expression (expression) of CPu in brainstem associated with medulla, raphe and withdrawal
12) Confidence 0.38 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.46 Pain Relevance 0.64
Following 24 h of withdrawal, there was an increase in PD and c-fos mRNA expression in the CPu and nucleus accumbens (NAc), and a decrease in PD and c-fos expression in hippocampus and amygdala.
Gene_expression (expression) of CPu in amygdala associated with nucleus accumbens, hippocampus, amygdala and withdrawal
13) Confidence 0.33 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.42 Pain Relevance 0.75
MCAo treated rats in our cohort showed lesions in both CPu (11 of 11 rats) and parietal cortex (8 of 11), two structures that are most consistently affected in this model of stroke.
Gene_expression (lesions) of CPu in parietal cortex associated with stroke
14) Confidence 0.33 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.54 Pain Relevance 0.16
While D1 receptors are found within the BST, mPOA, CeA, VMH, Arc, Hb, and CPu in adult rats [46]–[49], SKF 38393-induced increases in Fos are reduced by PSK 3668 only within the BST and CeA.
Gene_expression (found) of CPu associated with aids-related complex and amygdala
15) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.10 Pain Relevance 0.61
Treatment with the DA D1-like receptor agonist, SKF 38393, increased Fos expression within the AVPV, CPu, BST, mPOA, CeA, VMH, Arc, and Hb.
Gene_expression (expression) of CPu associated with dopamine, aids-related complex, agonist and amygdala
16) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.16 Pain Relevance 0.43
g Hg/kg, 20-week, ×100; g CPU, Control, 20-week, ×400; h CPU, 3,000 ?
Gene_expression (3,000) of CPU
17) Confidence 0.23 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.52 Pain Relevance 0.26
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Gene_expression (function) of CPu in hippocampus associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
18) Confidence 0.17 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0.06 Pain Relevance 0.56
A pronounced and time related decrease (25-65%) in prodynorphin gene expression was detected in AcbC, AcbS, CPu, hypothalamic supraoptic and paraventricular nuclei at all time points as well as in proopiomelanocortin gene expression (20-30%) in the arcuate nucleus (ARC) of the hypothalamus.
Gene_expression (detected) of CPu in CPu associated with aids-related complex
19) Confidence 0.14 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15936043 Disease Relevance 0.09 Pain Relevance 0.95
Following 24 h of withdrawal, there was an increase in PD and c-fos mRNA expression in the CPu and nucleus accumbens (NAc), and a decrease in PD and c-fos expression in hippocampus and amygdala.
Gene_expression (expression) of CPu in hippocampus associated with nucleus accumbens, hippocampus, amygdala and withdrawal
20) Confidence 0.11 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.42 Pain Relevance 0.75

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