INT13302

Context Info Confidence 0.48 First Reported 1986 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 20 Total Number 20 Disease Relevance 7.03 Pain Relevance 3.70

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR) signal transducer activity (PTAFR)

Anatomy Link Frequency platelet 8 eosinophil 2 tear 1 embryos 1 plasma 1 PTAFR (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 141 100.00 antagonist 80 100.00 Inflammatory mediators 35 100.00 Antihistamine 2 98.12 Inflammation 182 97.44 Pain 7 97.40 agonist 32 96.08 rheumatoid arthritis 42 94.84 cytokine 82 93.76 Potency 54 93.16

Disease Link Frequency Relevance Heat INFLAMMATION 211 100.00 Multiple Sclerosis 93 100.00 Wheal 2 100.00 Pain 9 97.40 Disease 167 97.36 Conjunctiva Disease 2 97.16 Injury 65 96.92 Neonatal Necrotizing Enterocolitis 68 96.32 Rheumatoid Arthritis 42 94.84 Chronic Disease 2 94.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As part of a general autacoid-serum protein binding screen, the platelet activating factor-alpha-1-acid glycoprotein (PAF-AAG) interaction was indirectly characterized by examining the ability of PAF to displace propranolol from AAG.

PAF Binding (interaction) of in platelet

1) Confidence 0.48 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.18 Pain Relevance 0.11

Furthermore, the interaction of PAF and AAG suggests that serum AAG, which fluctuates in a number of diseases, may function to regulate PAF activity during acute and chronic disease states.

PAF Binding (interaction) of associated with disease and chronic disease

2) Confidence 0.48 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.30 Pain Relevance 0.12

Drugs were tested for ability to inhibit maximum aggregation to PAF.

PAF Binding (aggregation) of

3) Confidence 0.37 Published 1991 Journal Prostaglandins Section Abstract Doc Link 1665568 Disease Relevance 0 Pain Relevance 0.19

BACKGROUND: Intradermal injection of platelet-activating factor (PAF) causes wheal and flare reactions, which are inhibited by antihistamines.

PAF Binding (injection) of in platelet associated with antihistamine and wheal

4) Confidence 0.37 Published 1997 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 9155831 Disease Relevance 0.10 Pain Relevance 0.05

BACKGROUND: Intradermal injection of platelet-activating factor (PAF) causes wheal and flare reactions, which are inhibited by antihistamines.

platelet-activating factor Binding (injection) of in platelet associated with antihistamine and wheal

5) Confidence 0.37 Published 1997 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 9155831 Disease Relevance 0.10 Pain Relevance 0.05

Clearly, PAF receptor antagonists represent useful therapeutic agents to combat ocular surface disorders where PAF may be released into the tear film.

PAF receptor Binding (represent) of in tear associated with antagonist

6) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.73 Pain Relevance 0.40

While a preliminary report indicated that specific binding sites for PAF were present on rabbit corneal epithelial cells [15], no such information is known for human conjunctival epithelial cells.

PAF Binding (binding) of in corneal epithelial cells

7) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 1.26 Pain Relevance 0.16

Furthermore, priming with PAF directly led to enhanced LPS-induced IL-8 secretion, thus showing the functional effect of increased TLR4 expression.

PAF Binding (priming) of

8) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.51 Pain Relevance 0.03

In summary, PAF has been recognized to play an important role in the development of the intestinal inflammatory injury seen in NEC.

PAF Binding (recognized) of associated with neonatal necrotizing enterocolitis, inflammation and injury

9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.52 Pain Relevance 0.16

PAF is an important chemoattractant and activator of immune cells, with special emphasis on eosinophils.38 PAF is among the most important inducers of eosinophil function and evokes the release of reactive oxygen species by immune cells39,40 and by esophageal circular muscle.41,42

PAF Binding (is) of in eosinophil

10) Confidence 0.27 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.13 Pain Relevance 0.61

In group A12, the platelet-activated receptor, a lipid receptor and receptors activated by nucleotides mingle, but are found on different side branches.

platelet-activated receptor Binding (mingle) of in platelet

11) Confidence 0.26 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0

PAF is an important chemoattractant and activator of immune cells, with special emphasis on eosinophils.38 PAF is among the most important inducers of eosinophil function and evokes the release of reactive oxygen species by immune cells39,40 and by esophageal circular muscle.41,42

PAF Binding (is) of in eosinophil

12) Confidence 0.24 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.14 Pain Relevance 0.64

With multiple (n) exposure categories, the PAF is given by the following generalized form: Although choosing zero as the reference exposure may be useful for some purposes, it is a restricting assumption for others.

PAF Binding (given) of

13) Confidence 0.16 Published 2003 Journal Popul Health Metr Section Body Doc Link PMC156894 Disease Relevance 0.53 Pain Relevance 0

On the other hand, a small Japanese study did find a significant association between MS susceptibility and a PAFR polymorphism causing a modest but significant reduction of PAF-dependent signaling [190].

PAFR Binding (association) of associated with multiple sclerosis

14) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.08 Pain Relevance 0.51

Gelsolin was shown to preferentially bind lysophosphatidic acid, platelet-activating factor, endotoxin, and lipoteichoic acid [20-22].

platelet-activating factor Binding (bind) of in platelet

15) Confidence 0.08 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.82 Pain Relevance 0.12

The plasma form of PAF-AH is associated with lipoproteins.

PAF Binding (associated) of in plasma

16) Confidence 0.07 Published 1999 Journal Cardiovasc. Res. Section Abstract Doc Link 10536703 Disease Relevance 0.16 Pain Relevance 0.30

Human embryos likewise release PAF in vitro, and human oviducts synthesize both the PAF receptor and PAF acetylhydrolase, which degrades PAF, further supporting a role for PAF in the embryo-oviductal dialogue [90].

PAF Binding (receptor) of in embryos

17) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266059 Disease Relevance 0.07 Pain Relevance 0

Cluster 16 is a heterogeneous group of receptors binding to lipids, nucleotides, modified nucleotides and platelet activating factor (PAF).

PAF Binding (binding) of in platelet

18) Confidence 0.02 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0.08 Pain Relevance 0.03

An association between platelet-activating factor (PAF) and myometrial contractions has been established.

platelet-activating factor Binding (association) of in platelet

19) Confidence 0.02 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9002656 Disease Relevance 0 Pain Relevance 0.08

Since pGSN has previously been shown to bind to various inflammatory mediators such as platelet-activating factor, lysophosphatidic acid, and endotoxin, some of which are present at higher-than-normal levels in the inflamed synovial joint of RA patients [44], further studies should be conducted to understand how this local consumption due to compartmental actin binding affects cell activation induced by these mediators.

platelet-activating factor Binding (bind) of in platelet associated with inflammatory mediators and rheumatoid arthritis

20) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.32 Pain Relevance 0.13

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