INT133079

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.03
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (GATA3) anatomical structure formation involved in morphogenesis (GATA3) DNA binding (GATA3)
signal transduction (GATA3) nucleolus (GATA3) nucleus (GATA3)
Anatomy Link Frequency
T cells 2
GATA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 99.72 Very High Very High Very High
Cannabinoid 8 91.48 High High
cytokine 19 87.32 High High
mu opioid receptor 1 81.08 Quite High
Morphine 1 80.96 Quite High
antagonist 2 78.60 Quite High
Cannabinoid receptor 2 75.00 Quite High
agonist 1 75.00 Quite High
Inflammation 41 74.88 Quite High
Opioid 2 53.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 80 98.36 Very High Very High Very High
Breast Cancer 24 84.48 Quite High
INFLAMMATION 41 74.88 Quite High
Carcinoma 1 68.84 Quite High
Apoptosis 2 53.36 Quite High
Colon Cancer 1 9.20 Low Low
Metastasis 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Graft Vs Host Disease 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors.
Positive_regulation (Upregulated) of Gene_expression (expression) of GATA3 associated with cancer
1) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.96 Pain Relevance 0
In addition, STAT6 induces expression of the transcription factor GATA3, which also contributes to mu-opioid receptor gene transcription.
Positive_regulation (contributes) of Gene_expression (expression) of GATA3 associated with opioid receptor
2) Confidence 0.40 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 1.03
The commitment of mouse and human CD4+ T cells to such distinct phenotypes is directed through expression of lineage specific transcription factors, e.g., Tbet for Th1, GATA3 for Th2, and ROR?
Positive_regulation (directed) of Gene_expression (expression) of GATA3 in T cells
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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