INT133083

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 3.27
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8ip1) signal transduction (Mapk8ip1) mitochondrion (Mapk8ip1)
vesicle-mediated transport (Mapk8ip1) endoplasmic reticulum (Mapk8ip1) nucleus (Mapk8ip1)
Anatomy Link Frequency
sciatic nerves 6
Mapk8ip1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 24 100.00 Very High Very High Very High
Sciatic nerve 18 100.00 Very High Very High Very High
Inflammation 6 81.84 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 24 100.00 Very High Very High Very High
Immunization 12 98.36 Very High Very High Very High
INFLAMMATION 6 81.84 Quite High
Apoptosis 3 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Positive_regulation (increased) of Gene_expression (expression) of p-JNK1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
1) Confidence 0.07 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 1.09 Pain Relevance 0.82
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Positive_regulation (increased) of Gene_expression (expression) of JNK1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
2) Confidence 0.06 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 1.09 Pain Relevance 0.82
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Positive_regulation (increased) of Gene_expression (expression) of p-JNK1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
3) Confidence 0.05 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 1.09 Pain Relevance 0.82

General Comments

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