INT13313

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Context Info
Confidence 0.07
First Reported 1981
Last Reported 2005
Negated 3
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.65
Pain Relevance 4.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRLR) plasma membrane (PRLR)
PRLR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 27 99.96 Very High Very High Very High
qutenza 3 99.48 Very High Very High Very High
Enkephalin 10 99.12 Very High Very High Very High
dopamine receptor 1 98.20 Very High Very High Very High
Morphine 9 96.84 Very High Very High Very High
analgesia 1 93.36 High High
Central grey 1 92.96 High High
opioid receptor 12 92.04 High High
mu opioid receptor 4 91.96 High High
Potency 2 90.92 High High
Disease Link Frequency Relevance Heat
Cough 3 98.76 Very High Very High Very High
Urological Neuroanatomy 2 92.96 High High
Endometriosis 5 87.60 High High
Reprotox - General 1 3 84.64 Quite High
Depression 1 84.00 Quite High
Reprotox - General 3 1 82.40 Quite High
Weight Gain 1 75.92 Quite High
Breast Disease 3 75.00 Quite High
Acne 1 73.84 Quite High
Hirsutism 1 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FSH and HPRL levels were not significantly affected.
Neg (not) Regulation (affected) of HPRL
1) Confidence 0.07 Published 1981 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 6798763 Disease Relevance 1.15 Pain Relevance 0.31
Thus, although the mutated residues are thought to be part of the binding pocket, they are critically involved in the control of the delta receptor activation process.
Regulation (control) of delta receptor
2) Confidence 0.03 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10777506 Disease Relevance 0 Pain Relevance 0.67
Effects of selective mu and delta receptor agonists on capsaicin-induced cough reflex in rats were studied.
Regulation (Effects) of delta receptor associated with qutenza, agonist and cough
3) Confidence 0.02 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1665789 Disease Relevance 0.32 Pain Relevance 0.67
In contrast, in the presence of added GTP or GTP gamma S, two affinity states were again apparent for DSLET competition at the delta receptor.
Regulation (apparent) of delta receptor
4) Confidence 0.00 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2833686 Disease Relevance 0 Pain Relevance 0.53
The present study extends this work by demonstrating that delta antisense DNA selectively affects the delta ncx-2 site sparing the other putative delta receptor subtypes and kappa 2 receptor subtypes.
Regulation (affects) of delta receptor
5) Confidence 0.00 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8584761 Disease Relevance 0 Pain Relevance 0.32
Administration of SKF 82958 had no affect on delta receptor binding, forskolin-stimulated adenylyl cyclase activity, or G protein/adenylyl cyclase coupling.
Neg (no) Regulation (affect) of delta receptor
6) Confidence 0.00 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698003 Disease Relevance 0 Pain Relevance 0.87
In contrast, the knockdown of RGSZ2 proteins did not affect the activity of delta receptor agonists, [D-Pen2,5]-enkephalin (DPDPE), and [D-Ala2] deltorphin II.
Neg (not) Regulation (affect) of delta receptor associated with agonist and enkephalin
7) Confidence 0.00 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15827571 Disease Relevance 0.18 Pain Relevance 1.40

General Comments

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