INT133169

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 13.00
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
macrophages 4
plasma 2
joints 1
bone marrow 1
lungs 1
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 61 99.90 Very High Very High Very High
psoriasis 26 98.44 Very High Very High Very High
rheumatoid arthritis 104 97.96 Very High Very High Very High
antagonist 17 96.92 Very High Very High Very High
Inflammatory mediators 17 96.48 Very High Very High Very High
Delta-9-tetrahydrocannabinol 9 95.84 Very High Very High Very High
cytokine 632 94.68 High High
cva 6 93.40 High High
agonist 78 90.96 High High
Inflammation 162 90.56 High High
Disease Link Frequency Relevance Heat
Infection 1101 99.84 Very High Very High Very High
Mycobacterial Infection 1615 99.60 Very High Very High Very High
Psoriasis 37 98.44 Very High Very High Very High
Cold Sores 428 98.00 Very High Very High Very High
Rheumatoid Arthritis 104 97.96 Very High Very High Very High
Sprains And Strains 341 97.92 Very High Very High Very High
Apoptosis 34 97.28 Very High Very High Very High
INFLAMMATION 193 96.08 Very High Very High Very High
Necrosis 25 93.92 High High
Hemorrhage 7 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our data are consistent with recent evidence showing that bioactive IL-23 (p19/p40) was barely detectable in joints of patients with RA [47].
Positive_regulation (bioactive) of p40 in joints associated with rheumatoid arthritis
1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.33 Pain Relevance 0.14
More recently, we demonstrated that 15d-PGJ2 and the thiazolidinedione rosiglitazone inhibited LPS induction of IL-12 p40,
Positive_regulation (induction) of IL-12 p40
2) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.45 Pain Relevance 0.24
IL-23 is composed of the IL-12p40 and a p19 subunit and likewise binds to a receptor with one of the IL-12 receptor subunits (IL-12R?
Positive_regulation (composed) of IL-12p40
3) Confidence 0.15 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.43 Pain Relevance 0.22
B-sequence of the IL-12p40 promoter binds NF-?
Positive_regulation (sequence) of IL-12p40
4) Confidence 0.15 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.07 Pain Relevance 0.07
Accordingly, we found that mRNAs encoding IL-12p40 (IL12B) and its receptor IL-12RB1 were induced in D21 M.tuberculosis-infected lungs (Table 2).
Positive_regulation (induced) of IL12B in lungs associated with mycobacterial infection and infection
5) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.77 Pain Relevance 0.21
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.


Positive_regulation (components) of IL-40 in keratinocytes associated with psoriasis and apoptosis
6) Confidence 0.07 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.53 Pain Relevance 0.21
mmaA4 TDM was attenuated in its ability to repress induction of IL-12p40 by LPS, and ?
Positive_regulation (induction) of IL-12p40
7) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.07 Pain Relevance 0
Increased induction of IL-12p40 and TNF-?
Positive_regulation (induction) of IL-12p40
8) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.26 Pain Relevance 0.07
mmaA4 mutant stimulated increased IL-12p40, similar to the increase observed from ?
Positive_regulation (increased) of IL-12p40
9) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2390761 Disease Relevance 0.91 Pain Relevance 0
In addition, our results strongly suggest that this enhanced induction of IL-12p40 could be mediated by the mycolate-containing glycolipid TDM, which is known to be secreted as a potential immunomodulator into the cytosol of infected macrophages.
Positive_regulation (induction) of IL-12p40 in macrophages
10) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.90 Pain Relevance 0
This attenuation was not seen in IL-12p40-deficient mice, consistent with a direct linkage between enhanced stimulation of IL-12p40 by the mutant and its reduced virulence.
Positive_regulation (stimulation) of IL-12p40
11) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2390761 Disease Relevance 0.83 Pain Relevance 0
This suppression of macrophage IL-12 production is likely to be responsible for increasing bacterial survival during innate immune response, given the critical role of IL-12p40 as a macrophage chemoattractant and in interferon gamma production [51]–[54].
Positive_regulation (role) of IL-12p40 in macrophage
12) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.63 Pain Relevance 0.13
The increased IL-12p40 and TNF-?
Positive_regulation (increased) of IL-12p40
13) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.36 Pain Relevance 0.04
mmaA4 mutant stimulated increased IL-12p40, similar to the increase observed from ?
Positive_regulation (stimulated) of IL-12p40
14) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2390761 Disease Relevance 0.92 Pain Relevance 0
Using an ELISA to quantitate IL-12p40 in the medium of bone marrow-derived macrophage cultures infected with either the ?
Positive_regulation (quantitate) of IL-12p40 in macrophage
15) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.43 Pain Relevance 0
mmaA4 mutant showed a reproducible increase in both IL-12p40 and TNF-?
Positive_regulation (increase) of IL-12p40
16) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.52 Pain Relevance 0.04
Mutants in which mmaA4 was inactivated induced more IL-12p40 from murine macrophages, and were attenuated for virulence in mice.
Positive_regulation (induced) of IL-12p40 in macrophages
17) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.59 Pain Relevance 0.04
Finally, maintenance and recall responses of immunological memory require both IL-12p70 and IL-23 (a dimer of p40 and p19) [16].
Positive_regulation (require) of IL-12p70
18) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.37 Pain Relevance 0.14
This analysis showed that TDMs from both sources reduced the LPS-induced IL-12p40 response, but that wild type TDM was significantly more potent in this regard than was ?
Positive_regulation (induced) of IL-12p40
19) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.33 Pain Relevance 0.13
The plasma level of IL-12p40 was significantly elevated as early as 6 h after the CpG-ODN challenge.
Positive_regulation (elevated) of IL-12p40 in plasma
20) Confidence 0.04 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.32 Pain Relevance 0.57

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