INT133176

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.86

cytoplasm (Mastl, Il12a) mitosis (Mastl) extracellular space (Il12a) extracellular region (Il12a) nucleus (Mastl) cytoskeleton (Mastl)

Anatomy Link Frequency dendritic cells 2 Mastl (Mus musculus) Il12a (Mus musculus)

Pain Link Frequency Relevance Heat Delta-9-tetrahydrocannabinol 9 100.00 antagonist 2 98.32 Cannabinoid receptor 4 96.60 cytokine 3 95.40 Cannabinoid 2 89.88 Endocannabinoid 1 72.64 qutenza 2 25.00

Disease Link Frequency Relevance Heat Targeted Disruption 1 91.60 Bordatella Infection 1 82.64 Infection 1 68.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that THC-induced suppression of serum IL-12 is partly due to a suppression of IL-12 production by dendritic cells and that G(i) signaling and cannabinoid receptors, but not TRPV1, are involved in this suppressive effect.

Regulation (due) of THC Negative_regulation (suppression) of IL-12 in dendritic cells associated with cannabinoid receptor and delta-9-tetrahydrocannabinol

1) Confidence 0.01 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.24 Pain Relevance 0.86

General Comments

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