INT133766

Context Info Confidence 0.56 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 12 Disease Relevance 11.28 Pain Relevance 2.27

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl) cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)

Anatomy Link Frequency poly 2 lymphocyte 1 cleavage 1 T cells 1 Fasl (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 51 99.98 Morphine 6 95.76 Inflammation 92 91.32 metalloproteinase 39 90.64 withdrawal 6 89.24 Chronic pancreatitis 6 86.04 dexamethasone 1 82.92 narcan 1 81.20 antagonist 3 80.48 Opioid 2 80.00

Disease Link Frequency Relevance Heat Targeted Disruption 11 99.98 Pancreatitis 8 99.44 Cerebral Toxoplasmosis 4 99.44 Lymphadenopathy 15 98.80 Death 137 98.60 Apoptosis 475 98.56 Sprains And Strains 9 98.20 Toxoplasmosis 12 98.04 Autoimmune Disease 99 96.04 Lymphoproliferative Disease 7 94.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blotting showed that a single injection of naltrexone (1 mg/kg) induced a down-regulation of the pro-apototic proteins Fas, FasL, Bad and Bax.

Negative_regulation (down-regulation) of FasL

1) Confidence 0.56 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.24 Pain Relevance 0.27

The transgenic FasL mRNA was highly expressed on days 2 to 10 and obviously decreased on day 20 after virus injection (Fig. 2, lanes 2–6), which suggests that repeated administration of FasL gene transfer would be necessary to maintain a high level of FasL transgene expression in vivo.

Negative_regulation (decreased) of FasL mRNA associated with targeted disruption

2) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.69 Pain Relevance 0.09

Concurrently, a down-regulation of the proapoptotic proteins FasL and Bad was detected in cortical lysates.

Negative_regulation (regulation) of FasL

3) Confidence 0.53 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.53 Pain Relevance 0.51

An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).

Negative_regulation (deficit) of FasL in poly associated with sprains and strains

4) Confidence 0.42 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.44 Pain Relevance 0.16

An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).

Negative_regulation (deficit) of gld in poly associated with sprains and strains

5) Confidence 0.41 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.44 Pain Relevance 0.16

To determine the consequences of the combined mutations on cell survival, we sorted several lymphocyte populations and subjected them in culture to cytokine deprivation, treatment with FasL, the calcium ionophore ionomycin, PMA, or the DNA damage-inducing drug etoposide.

Negative_regulation (deprivation) of FasL in lymphocyte associated with cytokine

6) Confidence 0.40 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.52 Pain Relevance 0.17

Finally, mouse Fas-Fc protein was used as a competitive inhibitor of Fas/Fas-L interactions [36].

Negative_regulation (inhibitor) of Fas-L

7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.70 Pain Relevance 0

Because sFasL is much less efficient than membrane-bound FasL at inducing Fas-mediated apoptosis in T cells, any mechanism that promotes FasL shedding can dramatically decrease FasL bioactivity [99, 100] thereby decreasing Fas-mediated apoptosis and promoting CD4+T cell-mediated autoimmunity. 9.

Negative_regulation (decrease) of FasL in T cells associated with autoimmune disease and apoptosis

8) Confidence 0.26 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.04 Pain Relevance 0.36

Subsequent experiments indicated that TCAH induced a mediated cleavage of FasL rather than suppressing FasL at the level of gene transcription [98].

Negative_regulation (suppressing) of FasL in cleavage

9) Confidence 0.26 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.22 Pain Relevance 0.19

To test this, lpr mice and gld mice which have defective Fas and FasL expressions respectively, were used [32,47].

Negative_regulation (defective) of FasL

10) Confidence 0.13 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.86 Pain Relevance 0.14

Fas/Fas ligand (FasL; CD178) are deficient in autoimmune lpr and gld mice, which develop profound lymphadenopathies.

Negative_regulation (deficient) of gld associated with lymphadenopathy

11) Confidence 0.13 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 1.84 Pain Relevance 0.18

As expected, this expression was absent in lpr and gld mice.

Negative_regulation (absent) of gld

12) Confidence 0.11 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.75 Pain Relevance 0.05

General Comments

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