INT133783

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.94
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a1) enzyme binding (Ugt1a1)
Anatomy Link Frequency
spinal cord 4
CAR 2
Ugt1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 86.92 High High
Inflammation 44 79.84 Quite High
Pain 3 78.40 Quite High
Paracetamol 3 72.04 Quite High
antagonist 1 63.60 Quite High
Spinal cord 4 50.00 Quite Low
Hyperalgesia 2 50.00 Quite Low
nociceptor 2 10.00 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Periodontitis 30 99.98 Very High Very High Very High
Sprains And Strains 1 99.98 Very High Very High Very High
Targeted Disruption 3 99.54 Very High Very High Very High
INFLAMMATION 45 79.84 Quite High
Pain 3 78.40 Quite High
Frailty 4 62.16 Quite High
Hyperalgesia 2 50.00 Quite Low
Alveolar Bone Loss 7 49.92 Quite Low
Hypercalcemia 2 25.64 Quite Low
Periodontal Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Greater than twofold increases in the expression of the B1 and TRPV-1 genes were detected in the injured region of the spinal cord in animals exhibiting hyperalgesia compared with animals with SCI that did not display hyperalgesia.
Positive_regulation (increases) of Gene_expression (expression) of B1 in spinal cord
1) Confidence 0.46 Published 2006 Journal Spine Section Body Doc Link 17108828 Disease Relevance 0.12 Pain Relevance 0
CONCLUSION: B1 and TRPV-1 receptor genes are overexpressed in the injured spinal cord of animals manifesting thermal hyperalgesia following SCI compared with similarly injured animals without hyperalgesia.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of B1 in spinal cord
2) Confidence 0.41 Published 2006 Journal Spine Section Body Doc Link 17108828 Disease Relevance 0 Pain Relevance 0
Taken together, these results indicate that nutritional status may gender-specifically influence the expression and activation of CAR and PPARalpha in liver cell nuclei, and this effect appears to be associated with alterations in UGT1A1 and UGT1A6 expression.
Positive_regulation (expression) of Gene_expression (expression) of UGT1A1 in CAR
3) Confidence 0.40 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.26
Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of B1 associated with targeted disruption and sprains and strains
4) Confidence 0.28 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497143 Disease Relevance 0.48 Pain Relevance 0.18
Hypericum treatment significantly prevented the periodontitis-mediated NF-kB p65 expression (Figure 3b, b1).
Positive_regulation (mediated) of Gene_expression (expression) of b1 associated with periodontitis
5) Confidence 0.13 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.34 Pain Relevance 0

General Comments

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