INT134009

From wiki-pain
Revision as of 14:00, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 2
AtT20 2
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
depression 11 99.92 Very High Very High Very High
Eae 1 94.24 High High
Neuropeptide 18 80.96 Quite High
dexamethasone 18 79.72 Quite High
antidepressant 3 75.00 Quite High
spastic colon 1 69.76 Quite High
cytokine 26 5.00 Very Low Very Low Very Low
Kinase C 24 5.00 Very Low Very Low Very Low
amygdala 16 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 11 99.92 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 95.52 Very High Very High Very High
Stress 57 79.88 Quite High
Sleep Disorders 1 71.20 Quite High
Chronic Fatigue Syndrome 1 70.80 Quite High
Functional Bowel Disorder 1 69.76 Quite High
Urticaria 1 67.84 Quite High
Hypersensitivity 1 67.44 Quite High
Common Cold 1 67.04 Quite High
Volume Depletion And Dehydration 4 38.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is probably undeniable that the cAMP/PKA pathway activates the vasopressin and CRH gene transcription, because of the large amount of evidence attesting to it; however, the whole picture about other regulators has not yet been fully elucidated.
Regulation (/) of Transcription (transcription) of CRH gene
1) Confidence 0.37 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.04
Three serial GRE half-sites are recognized in the above short sequences, all of which are involved in the negative regulation of the CRH gene transcription by the direct binding of GR. 8-bromo cAMP-induced CRH gene promoter activity is significantly reduced by glucocorticoid in AtT20 cells; however, this suppressive effect is abolished in the deleted or mutated construct lacking these nGRE site(s).
Regulation (regulation) of Transcription (transcription) of CRH gene in AtT20
2) Confidence 0.37 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.10
Levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary were significantly increased, and glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus was downregulated in the depression-like model mice.
Regulation (Levels) of Transcription (expression) of corticotropin-releasing hormone mRNA in hypothalamus associated with depression
3) Confidence 0.34 Published 2006 Journal Phytomedicine Section Abstract Doc Link 16516452 Disease Relevance 1.10 Pain Relevance 0.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox