INT134316

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 8.44
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
heart 1
RT1-Hb-ps1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 16 96.84 Very High Very High Very High
depression 48 94.36 High High
fluoxetine 1 92.24 High High
tail-flick 3 91.08 High High
cva 41 83.44 Quite High
Pain 24 81.92 Quite High
sSRI 4 79.52 Quite High
Pain threshold 1 75.68 Quite High
diabetic neuropathy 5 75.00 Quite High
Inflammation 25 52.24 Quite High
Disease Link Frequency Relevance Heat
Hyperlipidemia 10 99.96 Very High Very High Very High
Hyperinsulinism 1 99.80 Very High Very High Very High
Diabetes Mellitus 328 99.34 Very High Very High Very High
Insulin Resistance 14 98.44 Very High Very High Very High
Myocardial Infarction 10 98.40 Very High Very High Very High
Generalized Anxiety Disorder 16 97.76 Very High Very High Very High
Stroke 1 97.76 Very High Very High Very High
Coronary Artery Disease 16 96.72 Very High Very High Very High
Increased Venous Pressure Under Development 3 96.08 Very High Very High Very High
Depression 64 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sucrose caused remarkable increase of BG and HbA1c in the OLETF rats, but not in the sucrose-fed LETO rats.
Positive_regulation (increase) of HbA1c
1) Confidence 0.32 Published 2006 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 16541192 Disease Relevance 0.56 Pain Relevance 0.30
In a study with sertraline, glycosylated hemoglobin (HbA1c) levels were reduced during treatment, but did not differ between the sertraline and placebo groups,15,16 whereas no significant reduction in HbA1c levels was observed in patients treated with fluoxetine or paroxetine, although their depressive symptoms were significantly improved.17 Similarly, although escitalopram resulted in a significant reduction of depression score, there was only a small and nonsignificant reduction in fasting blood glucose (FBG) levels and HbA1c levels.18 It would thus appear that selective serotonin reuptake inhibitors (SSRIs) do not have any major effect on metabolic control, even when they produce a significant effect on depressive symptoms.
Positive_regulation (glycosylated) of HbA1c in blood associated with depression, ssri and fluoxetine
2) Confidence 0.10 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2819761 Disease Relevance 1.92 Pain Relevance 0.72
= -,055) of decreasing prevalence of chronic non-widespread MSCs with increasing HbA1c.


Positive_regulation (increasing) of HbA1c
3) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2611990 Disease Relevance 1.14 Pain Relevance 0
Fasting glucose, glycosylated hemoglobin (HbA1c), C-peptide and anti-glutamic acid decarboxylase (anti-GAD) was drawn from 74% of the participants with a positive answer to the question "Do you have or have you ever had diabetes?"
Positive_regulation (glycosylated) of HbA1c associated with diabetes mellitus and generalized anxiety disorder
4) Confidence 0.03 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2611990 Disease Relevance 0.96 Pain Relevance 0.38
In a meta-analysis on 7,500 diabetic patients a one percentage point increase in HbA1c was linked to an 18% increased risk of heart attack or stroke, and a 28% increase in the risk of peripheral vascular disease.
Positive_regulation (increase) of HbA1c in heart associated with stroke, diabetes mellitus, increased venous pressure under development and myocardial infarction
5) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597754 Disease Relevance 2.03 Pain Relevance 0.30
Therefore, at the beginning of the study (initial time: 20 weeks of age) the diabetic rats presented hyperglycaemia, hypercholesterolaemia, hypertriglyceridaemia, increased HbA1c and hyperinsulinaemia, accompanied by insulin resistance (HOMA-IR).
Positive_regulation (increased) of HbA1c associated with diabetes mellitus, hyperinsulinism, insulin resistance and hyperlipidemia
6) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 1.82 Pain Relevance 0.05

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