INT134338

Context Info Confidence 0.65 First Reported 2006 Last Reported 2010 Negated 4 Speculated 0 Reported most in Body Documents 23 Total Number 24 Disease Relevance 13.01 Pain Relevance 1.38

extracellular region (CD55) plasma membrane (CD55)

Anatomy Link Frequency erythrocytes 2 neck muscle 1 blood 1 joint 1 granulocytes 1 CD55 (Homo sapiens)

Pain Link Frequency Relevance Heat cryotherapy 14 99.98 Inflammation 131 98.56 abdominal pain 6 89.36 agonist 52 83.92 peptic ulcer disease 1 79.56 Angina 2 75.56 Inflammatory mediators 9 64.68 tetrodotoxin 12 59.80 Pain 32 50.00 Migraine 8 50.00

Disease Link Frequency Relevance Heat Cleidocranial Dysplasia 31 100.00 Paroxysmal Nocturnal Hemoglobinuria 173 99.66 Lifespan 2 99.64 Hemolysis 58 99.52 Obesity 46 99.24 INFLAMMATION 142 98.56 Communicable Diseases 1 98.16 Infection 84 97.92 Anaemia 21 96.76 Esophageal Stenosis 2 96.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

DAF and HM conducted the RCT and analysed the data.

Gene_expression (conducted) of DAF

1) Confidence 0.65 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1868722 Disease Relevance 0.47 Pain Relevance 0

For nitric oxide synthase (NOS) activity measurements, 3 week in vitro primary striatal cultures were preincubated with DMEM containing DAF-FM DA (Molecular Probes; 10 µM) for 30 min at 37°C.

Gene_expression (containing) of DAF

2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0

A flow cytometry evaluation of CD55 and/or CD59, CD59, and CD48 expression in erythrocytes, granulocytes, and monocytes, respectively, showed that the respective proportions of negative populations were 5.6%, 97.1%, and 96.2%.

Gene_expression (expression) of CD55 in monocytes

3) Confidence 0.62 Published 2007 Journal Int. J. Hematol. Section Abstract Doc Link 17988986 Disease Relevance 1.72 Pain Relevance 0.09

RESULTS: Compared with controls, individuals with TM had numerically inferior CROM in all parameters, and significant reduction in 3 of them: extension (59.3 vs 68.1, P = .02), left lateral flexion (44.5 vs 49.1, P = .03), and right rotation (62.2 vs 69.6, P = .02).

Gene_expression (reduction) of CROM in lateral

4) Confidence 0.59 Published 2009 Journal Headache Section Body Doc Link 18783446 Disease Relevance 0.07 Pain Relevance 0

The CROM was not reduced for the symptomatic side of migraine, in cases of unilateral pain.

Neg (not) Gene_expression (reduced) of CROM

5) Confidence 0.59 Published 2009 Journal Headache Section Body Doc Link 18783446 Disease Relevance 0 Pain Relevance 0

METHODS: CROM measures were collected from 25 symptomatic and 42 asymptomatic individuals using VR and conventional assessments.

Gene_expression (measures) of CROM

6) Confidence 0.54 Published 2010 Journal Spine Section Body Doc Link 20110842 Disease Relevance 0 Pain Relevance 0

On the other hand, expression of decay accelerating factor (CD55) increased 1.3 times as a result of trypsin treatment.

Gene_expression (expression) of CD55

7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.17 Pain Relevance 0.18

On the other hand, expression of decay accelerating factor (CD55) increased 1.3 times as a result of trypsin treatment.

Gene_expression (expression) of decay accelerating factor

8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.17 Pain Relevance 0.18

Adipose tissue-derived stem cells are understood to express surface markers of CD9, CD10, CD13, CD29, CD44, CD49d, CD49e, CD54, CD55, CD59, CD73, CD90, CD105, CD146, CD166, and STRO-1, and lack hematopoietic lineage markers CD11b, CD14, CD19, CD34, and CD45 [20,34,50-53].

Neg (lack) Gene_expression (express) of CD55 in stem cells associated with obesity

9) Confidence 0.43 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.17 Pain Relevance 0.06

The intensity of red colour over yellow colour in the normalized GERP-DAF matrix and coding GERP matrix for a functional category shows the extent of over-representation in respective bins over the genome-wide background.

Gene_expression (matrix) of DAF

10) Confidence 0.43 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0

Any SNP in the dataset was placed into the appropriate bin of the 3 × 3 'divergence-DAF matrix' according to its GERP score and DAF in a given HapMap population.

Gene_expression (score) of DAF

11) Confidence 0.43 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0

We reported that membrane-bound CRegs—MCP, DAF, and CD59—are differentially expressed in normal human and eyes [33].

Gene_expression (expressed) of DAF in eyes

12) Confidence 0.42 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.06 Pain Relevance 0.03

Membrane-bound CRegs such as MCP, DAF, Crry (Fig. 2a), and CD59 (Fig. 2b) are expressed in the different layers of the cornea to protect this tissue from complement-mediated damage [27, 33, 50].

Gene_expression (expressed) of DAF in cornea

13) Confidence 0.42 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.58 Pain Relevance 0.05

Divergence-DAF joint distribution

Gene_expression (distribution) of Divergence-DAF in joint

14) Confidence 0.37 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0

At the same time, the GERP-DAF distribution shows that there is an excess of nonsynonymous polymorphic positions with high conservation in mammals and high derived allele frequency in humans, suggesting the positions are evolving in a manner unique to humans.

Gene_expression (distribution) of DAF

15) Confidence 0.37 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0

His peripheral blood was negative for the JAK2 V617F point mutation, and showed normal expression of CD55 and CD59.

Gene_expression (expression) of CD55 in blood

16) Confidence 0.35 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2873355 Disease Relevance 0.31 Pain Relevance 0

A low level of complement activation is a constant physiological phenomenon greatly amplified during inflammatory or infectious diseases; thus, PNH erythrocytes chronically undergo intravascular hemolysis in PNH patients due to CD55 and CD59 deficiency, with a lifespan reduced to 10% compared with that of normal RBCs (Wiedmer et al 1993).

Gene_expression (deficiency) of CD55 in RBCs associated with inflammation, lifespan, hemolysis, paroxysmal nocturnal hemoglobinuria and communicable diseases

17) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.24 Pain Relevance 0.05

In 17 HGD patients, cryotherapy produced CR-HGD, CR-D, and CR-IM of 94%, 88%, and 53%, respectively.

Gene_expression (produced) of CR-D associated with cleidocranial dysplasia and cryotherapy

18) Confidence 0.23 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515183 Disease Relevance 1.82 Pain Relevance 0.21

In vitro studies showed that H. pylori adhered avidly to Chinese hamster ovary cells expressing human DAF but not to vector controls.

Neg (not) Gene_expression (expressing) of DAF in ovary

19) Confidence 0.21 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16543227 Disease Relevance 0.61 Pain Relevance 0.15

A flow cytometry evaluation of CD55 and/or CD59, CD59, and CD48 expression in erythrocytes, granulocytes, and monocytes, respectively, showed that the respective proportions of negative populations were 5.6%, 97.1%, and 96.2%.

Gene_expression (expression) of CD55 in erythrocytes

20) Confidence 0.21 Published 2007 Journal Int. J. Hematol. Section Abstract Doc Link 17988986 Disease Relevance 1.72 Pain Relevance 0.09

General Comments

This test has worked.