INT134342

Context Info Confidence 0.35 First Reported 2001 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 7 Total Number 9 Disease Relevance 1.83 Pain Relevance 0.28

extracellular region (CD55) plasma membrane (CD55)

Anatomy Link Frequency eyes 1 Neck 1 leukocytes 1 epithelial cells 1 CD55 (Homo sapiens)

Pain Link Frequency Relevance Heat peptic ulcer disease 1 94.12 cva 3 77.12 spinal inflammation 3 77.12 Inflammation 62 75.00 Pain 25 50.00 cytokine 28 33.76 Crohn's disease 14 5.00 alcohol 8 5.00 tolerance 5 5.00 Inflammatory response 3 5.00

Disease Link Frequency Relevance Heat Adenocarcinoma 22 95.48 Sprains And Strains 20 94.24 Disease 73 94.12 Ulcers 15 93.80 Dengue 64 93.52 Infection 101 92.84 Gastritis 3 91.72 Hemorrhage 3 77.12 Low Back Pain 3 77.12 Shock 4 75.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Runaway complement activation is prevented by binding of Complement Receptor 1 (CR1) and a constitutively active membrane bound Decay Accelerating Factor (DAF, or CD55) which can prevent the complement cascade[51].

DAF Binding (bound) of

1) Confidence 0.35 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.54 Pain Relevance 0.04

CONCLUSION: Neck pain is significantly associated with reduced CROM as demonstrated by both VR and conventional assessment methods.

CROM Binding (associated) of in Neck

2) Confidence 0.34 Published 2010 Journal Spine Section Body Doc Link 20110842 Disease Relevance 0 Pain Relevance 0

Construct validity of the CROM was determined by comparing CROM with radiographics, a single inclinometer and opto-electronic systems [33, 55, 69–71].

CROM Spec (determined) Binding (comparing) of

3) Confidence 0.31 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443270 Disease Relevance 0.16 Pain Relevance 0.08

If, on the other hand, a pair of functional categories is dissimilar both in coding GERP matrix and GERP-DAF matrix, they will have a large distance in D.

DAF Binding (matrix) of

4) Confidence 0.24 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0

We reported that membrane-bound CRegs—MCP, DAF, and CD59—are differentially expressed in normal human and eyes [33].

DAF Binding (membrane-bound) of in eyes

5) Confidence 0.20 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.06 Pain Relevance 0.03

However, DAF does not irreversibly inactivate C3b and C4b and, after interaction with DAF, these molecules still possess cytolytic activity.

DAF Binding (interaction) of

6) Confidence 0.20 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0

CD97, a glycoprotein that is present on the surface of most activated leukocytes, has been shown to interact with CD55 (decay-accelerating factor), a glycosyl-phosphatidylinositol-linked cell-surface molecule that plays a role in regulating complement activation [26].

CD55 Binding (interact) of in leukocytes

7) Confidence 0.19 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0 Pain Relevance 0

Decay-accelerating factor (DAF), a protein that protects epithelial cells from complement-mediated lysis, also functions as a receptor for several microbial pathogens.

DAF Binding (receptor) of in epithelial cells

8) Confidence 0.13 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16543227 Disease Relevance 0.62 Pain Relevance 0.13

The influence on E. coli binding of the two known single amino acid polymorphisms within short consensus repeat (SCR) domains of CD55 was examined by Pham et al. [71] and Nowicki et al [72].

CD55 Spec (examined) Binding (binding) of

9) Confidence 0.10 Published 2006 Journal J Transl Med Section Body Doc Link PMC1479838 Disease Relevance 0.45 Pain Relevance 0

General Comments

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