INT134590

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 8.43
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ADA) aging (ADA) cytoplasm (ADA)
cytosol (ADA) extracellular space (ADA) cell adhesion (ADA)
Anatomy Link Frequency
visceral 1
Monocyte 1
capsules 1
CSF 1
chest 1
ADA (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 423 100.00 Very High Very High Very High
adenocard 96 100.00 Very High Very High Very High
Infliximab 211 99.60 Very High Very High Very High
Inflammation 31 99.54 Very High Very High Very High
rheumatoid arthritis 138 99.36 Very High Very High Very High
cINOD 14 93.20 High High
spinal inflammation 59 92.48 High High
Pain 3 90.36 High High
pruritus 2 90.12 High High
corticosteroid 40 90.08 High High
Disease Link Frequency Relevance Heat
Communicable Diseases 10 99.84 Very High Very High Very High
Disease 232 99.72 Very High Very High Very High
INFLAMMATION 26 99.54 Very High Very High Very High
Fever 121 99.52 Very High Very High Very High
Rheumatoid Arthritis 138 99.36 Very High Very High Very High
Infection 40 99.20 Very High Very High Very High
Bacterial Pneumonia 4 98.32 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 97.48 Very High Very High Very High
Mycobacterial Infection 25 96.92 Very High Very High Very High
Pressure And Volume Under Development 4 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems to be associated with the differentiation of epithelial cells and monocytes and with neurotransmission.33 Monocyte/macrophage activation by intracellular infection and inflammatory diseases leads to the release of ADA and elevated levels in the serum.34 Monocyte involvement in CCHF has been well described.19 However, no studies have reported the ADA/XO levels in patients with CCHF.
Localization (release) of ADA in Monocyte associated with inflammation, fever, disease and infection
1) Confidence 0.65 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.46 Pain Relevance 0.05
It is not known, however, when these patients became ANA positive, as it appears these measurements were not conducted during or after IFX therapy nor before ADA use.
Localization (use) of ADA associated with infliximab and adalimumab
2) Confidence 0.63 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 1.28 Pain Relevance 0.63
A case report by Boura et al (2006) has described the occurrence, 4 hours after a second infusion of ADA for refractory RA, of a violaceous plaque, emerging as an erythematous urticarial edema and associated with systemic manifestations (chest discomfort, epigastralgia, fever 38.4 °C, rigor, fatigue, and malaise), which was successfully treated with corticosteroids and antibiotics.
Localization (infusion) of ADA in chest associated with pressure and volume under development, corticosteroid, rheumatoid arthritis, fatigue, adalimumab, fever and rigor
3) Confidence 0.63 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 1.45 Pain Relevance 0.79
Increased serum ADA has been reported in infectious diseases such as viral and bacterial pneumonia, HIV infection, extra-pulmonary and pulmonary tuberculosis, visceral leishmaniasis, and mononucleosis.21,22,25
Localization (reported) of serum ADA in visceral associated with leishmaniasis, mycobacterial infection, bacterial pneumonia, acquired immune deficiency syndrome or hiv infection, communicable diseases and infection
4) Confidence 0.61 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.45 Pain Relevance 0.05
She recovered by antibiotics for 45 days and ADA level in CSF was normalized.
Localization (level) of ADA in CSF
5) Confidence 0.29 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19928691 Disease Relevance 0.83 Pain Relevance 0.16
Occurrence of TPO, TG, AMA, LKM, SMA, ADA and ANCA autoantibodies
Localization (Occurrence) of ADA
6) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.96 Pain Relevance 1.40
This would imply that the timing of the pH-dependent release of ATP/adenosine by the enteric-coated capsules might be an important factor limiting the effectiveness of these compounds.
Localization (release) of adenosine in capsules associated with adenocard
7) Confidence 0.08 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1913056 Disease Relevance 0 Pain Relevance 0.36
Fine-tuning modulation of myenteric motoneurons by endogenous adenosine: on the role of secreted adenosine deaminase.
Localization (secreted) of deaminase in motoneurons associated with adenocard
8) Confidence 0.01 Published 2006 Journal Auton Neurosci Section Title Doc Link 16563876 Disease Relevance 0 Pain Relevance 0.52

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