INT134661

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 10.91
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
liver 1
GALT 1
fibroblasts 1
RG2 1
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 10 99.92 Very High Very High Very High
endometriosis 69 96.92 Very High Very High Very High
nud 1 96.44 Very High Very High Very High
Sciatic nerve 12 81.60 Quite High
cytokine 19 80.64 Quite High
ketamine 4 67.68 Quite High
Spinal cord 8 63.36 Quite High
rheumatoid arthritis 16 56.48 Quite High
Neuropeptide 7 50.00 Quite Low
metalloproteinase 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 218 99.92 Very High Very High Very High
Cancer 206 99.70 Very High Very High Very High
Prostate Cancer 37 99.24 Very High Very High Very High
INFLAMMATION 40 99.20 Very High Very High Very High
Nerve Sheath Neoplasms 13 98.88 Very High Very High Very High
Tetraploidy 1 98.80 Very High Very High Very High
Myocardial Infarction 156 98.76 Very High Very High Very High
Aneuploidy 1 98.16 Very High Very High Very High
Ovarian Cancer 6 97.96 Very High Very High Very High
Colon Cancer 18 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of

the p53 gene renders cells less susceptible to undergo apoptosis [12].

Negative_regulation (Inactivation) of p53 associated with apoptosis
1) Confidence 0.43 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.11 Pain Relevance 0.03
Decreased Sirt1- mediated p53-acetylation has been shown to be associated with a decrease in p53-mediated apoptosis.
Negative_regulation (decrease) of p53 associated with apoptosis
2) Confidence 0.26 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.24 Pain Relevance 0
Acetylation of p53 at the Sirt1-preferred site was decreased in the LV remote area in post-MI GK rats compared to GK sham and post-MI Wistar rats (Figure 6D) as assessed by western blotting.


Negative_regulation (decreased) of p53 associated with myocardial infarction
3) Confidence 0.25 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.36 Pain Relevance 0
Many of the genetic lesions involved in BE neoplastic progression are known, including loss of CDKN2A (p16) and TP53 (p53) and the development of tetraploidy and aneuploidy.
Negative_regulation (loss) of TP53 associated with aneuploidy and tetraploidy
4) Confidence 0.22 Published 2006 Journal J Natl Compr Canc Netw Section Abstract Doc Link 16569389 Disease Relevance 0.71 Pain Relevance 0.13
Genetic polymorphisms in TP53, nonsteroidal anti-inflammatory drugs and the risk of colorectal cancer: evidence for gene-environment interaction?
Negative_regulation (polymorphisms) of TP53 associated with inflammation, colon cancer and cinod
5) Confidence 0.20 Published 2007 Journal Pharmacogenet. Genomics Section Title Doc Link 17622940 Disease Relevance 0.72 Pain Relevance 0.35
However, since inactivation of p53 is a critical event during hepatocarcinogenesis, it has been suggested that miRNAs play a central role in the aberrance of the p53 tumor suppressor network during neoplastic transformation of liver cancer stem cells, and that this is linked with multiple changes of phenotype such as cell cycle arrest and apoptosis.
Negative_regulation (inactivation) of p53 in liver associated with liver cancer, cancer and apoptosis
6) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 0.97 Pain Relevance 0
These alterations include inactivation of cell-cycle associated genes such as TP53, RB1 and CDKN2A which encodes p16(INK4A) and p14(ARF) [16,17].
Negative_regulation (inactivation) of TP53
7) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2924852 Disease Relevance 0.98 Pain Relevance 0.03
Goumenou et al. [35], by microsatellite analysis, demonstrated that loss of heterozygosity on p16(Ink4), GALT, and p53, as well as on APOA2, a region frequently lost in ovarian cancer, occurs in endometriosis, even in stage II of the disease.
Negative_regulation (loss) of p53 in GALT associated with endometriosis, ovarian cancer and disease
8) Confidence 0.10 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 1.67 Pain Relevance 0.45
For prostate cancer all early-stage cancer has an intact p53 gene that is suppressed from acting, as we will discuss later.
Negative_regulation (suppressed) of p53 associated with cancer and prostate cancer
9) Confidence 0.09 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538507 Disease Relevance 0.91 Pain Relevance 0
In RG2 cells, the genes of p53 and p16 are impaired and exhibit homologous deletion, and these were undetectable in immunoblotting analysis.
Negative_regulation (impaired) of p53 in RG2
10) Confidence 0.09 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.70 Pain Relevance 0
We examined whether p53 deficiency affects WOX1
                   functions. p53 wild-type C57BL/six (p53+/+) and
                   knockout p53N4-M (p53+/? 
Spec (whether) Negative_regulation (deficiency) of p53 associated with targeted disruption
11) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.28 Pain Relevance 0.14
In line with this, we observed that the number of p53 deficient mouse embryonic fibroblasts was also reduced by IFN?
Negative_regulation (reduced) of p53 in fibroblasts
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.27 Pain Relevance 0

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