INT134747

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.44
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (SV2A) endoplasmic reticulum (SV2A) cytoplasm (SV2A)
Anatomy Link Frequency
row 1
CAR 1
brain 1
SV2A (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 64 99.86 Very High Very High Very High
substance P 24 97.52 Very High Very High Very High
cytokine 2 83.56 Quite High
Inflammation 2 83.20 Quite High
Neuropeptide 6 81.28 Quite High
Morphine 8 79.20 Quite High
GABAergic 7 75.72 Quite High
Opioid 4 75.00 Quite High
Calcitonin gene-related peptide 11 67.84 Quite High
Neurotransmitter 32 67.76 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 4 99.60 Very High Very High Very High
INFLAMMATION 2 83.20 Quite High
Generalized Anxiety Disorder 19 5.00 Very Low Very Low Very Low
Colon Cancer 8 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Liver Cancer 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Dyskinesias 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The eukaryotic expression plasmid for CAR(SV5) was constructed by cloning the 910 bp EcoRI/XmaI insert fragment of pcDhCAR(SV1) and the 130 bp XmaI/HindIII insert fragment of a pGEM exon 8–9 clone (see above) containing the deletion in exon 9 into appropriately digested vector pcDNA3.1(-) (Invitrogen).
Gene_expression (expression) of SV5 in CAR
1) Confidence 0.72 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
In NMB cells expressing human MOR gene, transfection of SV1 or SV2 reduced binding activity of the endogenous MOR.
Gene_expression (transfection) of SV2 associated with opioid receptor
2) Confidence 0.56 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.08 Pain Relevance 0.69
In a receptor binding assay, cells expressing the SV1 and SV2 do not exhibit binding to [(3)H]diprenorphine.
Gene_expression (expressing) of SV2
3) Confidence 0.56 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.10 Pain Relevance 0.81
Thus we obtained eukaryotic expression plasmids (pcDhCAR) for transcripts SV1, SV2, SV4 and SV6.
Gene_expression (expression) of SV4
4) Confidence 0.56 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Thus we obtained eukaryotic expression plasmids (pcDhCAR) for transcripts SV1, SV2, SV4 and SV6.
Gene_expression (expression) of SV2
5) Confidence 0.56 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Thus we obtained eukaryotic expression plasmids (pcDhCAR) for transcripts SV1, SV2, SV4 and SV6.
Gene_expression (expression) of SV6
6) Confidence 0.56 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
SV1 and SV2 of hMOR were present in human neuroblastoma NMB cells and human whole brain confirmed by RT-PCR.
Gene_expression (present) of SV2 in brain associated with neuroblastoma
7) Confidence 0.50 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.10 Pain Relevance 0.77
In vitro translation of SV1 and SV2 produced proteins with the predicted molecular weights.
Gene_expression (produced) of SV2
8) Confidence 0.50 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.08 Pain Relevance 0.67
As shown in Figure 2, quantitative analysis of SVOP labeling showed saturation with an apparent Kd value of 83 µM, a value within physiological concentrations of ATP in cells, and similar to the apparent Kd values measured for SV2 (?
Gene_expression (measured) of SV2
9) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669215 Disease Relevance 0 Pain Relevance 0
D12 cells expressed both synaptic proteins (SV2 –second row, first panel; Syn –fourth row, first panel), and SP (second and fourth rows, second panel), with co-localization throughout the cell body and neurites (Merge –second and fourth rows, fourth panel).
Gene_expression (expressed) of SV2 in row associated with substance p
10) Confidence 0.33 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.08 Pain Relevance 0.55

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