INT134890

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Context Info
Confidence 0.79
First Reported 2006
Last Reported 2007
Negated 2
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.75
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
neutrophils 3
T lymphocytes 2
endothelial cells 1
fibroblast 1
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 187 99.84 Very High Very High Very High
rheumatoid arthritis 348 98.52 Very High Very High Very High
aspirin 6 94.20 High High
cINOD 7 88.24 High High
cytokine 72 78.72 Quite High
chemokine 1 76.96 Quite High
antagonist 6 69.36 Quite High
Osteoarthritis 60 38.80 Quite Low
Arthritis 24 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 182 99.84 Very High Very High Very High
Rheumatoid Arthritis 348 98.52 Very High Very High Very High
Disease 13 84.84 Quite High
Diabetes Mellitus 1 84.12 Quite High
Increased Venous Pressure Under Development 2 82.64 Quite High
Disease Progression 6 81.84 Quite High
Apoptosis 48 62.56 Quite High
Necrosis 54 61.56 Quite High
Cancer 54 61.20 Quite High
Immune System Diseases 6 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PBMLs cultured under similar conditions secreted RANK-L and OPG in the supernatants (data not shown), confirming that neutrophils and PBMLs expressed RANK-L and OPG differently.


Localization (secreted) of RANK in neutrophils
1) Confidence 0.79 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.29 Pain Relevance 0.18
On the other hand, given that RANK-L was not released by inflammatory neutrophils (Figure 2a), the low amounts of RANK-L measured in the same SF (see Results section) could originate only from lining fibroblast-like synoviocytes [41].
Neg (not) Localization (released) of RANK in fibroblast associated with inflammation
2) Confidence 0.79 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.63 Pain Relevance 0.26
SF neutrophils obtained from patients with RA and incubated for up to 4 days in CM (as described in Materials and methods and Figure 2a) or in SM (data not shown) did not release RANK-L.
Neg (not) Localization (release) of RANK in neutrophils associated with rheumatoid arthritis
3) Confidence 0.79 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.57 Pain Relevance 0.29
From that point of view, neutrophils are different from other cell types such as osteoblasts, fibroblasts, or T lymphocytes, which produce RANK-L and release soluble RANK-L after stimulation [17,24,30,31].
Localization (release) of RANK in T lymphocytes
4) Confidence 0.74 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.58 Pain Relevance 0.25
In contrast, SF neutrophils from patients with RA not only express the membrane-associated form of RANK-L but also express RANK and secrete OPG.
Localization (secrete) of RANK in neutrophils associated with rheumatoid arthritis
5) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.59 Pain Relevance 0.29
From that point of view, neutrophils are different from other cell types such as osteoblasts, fibroblasts, or T lymphocytes, which produce RANK-L and release soluble RANK-L after stimulation [17,24,30,31].
Localization (release) of RANK in T lymphocytes
6) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.58 Pain Relevance 0.25
To test this assumption, as well as the possible mechanisms involved, the MCP-1 expression and secretion, the reactive oxygen species levels, nuclear factor-kB (NF-kB) and activator protein-1 (AP-1) expression were determined in human endothelial cells exposed to high glucose concentrations in the presence of aspirin, fenofibrate and clofibrate.
Spec (determined) Localization (secretion) of NF-kB in endothelial cells associated with aspirin
7) Confidence 0.35 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.51 Pain Relevance 0.34

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