INT134981

Context Info Confidence 0.49 First Reported 2006 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.69 Pain Relevance 0.10

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B) aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)

IL1B (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 100.00 cytokine 3 50.00 headache 2 5.00 backache 2 5.00 Chronic pancreatitis 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 2 100.00 Pancreatitis 3 95.28 Apoptosis 7 91.56 Adhesions 1 70.60 Venezuelan Equine Encephalomyelitis 9 50.00 Togavirus Infection 2 46.48 Infection 10 30.64 Viral Infection 2 21.44 Vomiting 4 5.00 Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Exposure to the VEEV has also induced the up regulation of pro-inflammatory genes such as IL-6, IFN-b, IL-1a, IL1-b and the Fas ligand.

Positive_regulation (induced) of Regulation (regulation) of IL1-b associated with inflammation

1) Confidence 0.49 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.59 Pain Relevance 0.10

RESULTS: At early stages and height of CAP exacerbation, concentrations of IL-1beta, IL-6, IL-8, TNF-gamma and TNFalpha were elevated (951.1 +/- 104.2 pg/ml; 172.8 +/- 24.3 pg/ml; 432.6 +/- 68.5 pg/ml; 823.3 +/- 97.5 pg/ml; 158.7 +/- 19.6 pg/ml, respectively).

Positive_regulation (elevated) of Regulation (concentrations) of IL-1beta

2) Confidence 0.45 Published 2006 Journal Ter. Arkh. Section Body Doc Link 16613100 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.