INT135062

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gli3) intracellular (Gli3) cilium (Gli3)
DNA binding (Gli3) cytoplasm (Gli3) cytosol (Gli3)
Gli3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 10 96.96 Very High Very High Very High
opiate 2 86.40 High High
Kappa opioid receptor 2 84.36 Quite High
Enkephalin 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that PDN transcription is regulated by DREAM in a calcium-dependent manner and suggest a role for dynorphin regulation of alpha-cell glucagon secretion.
Transcription (transcription) of PDN associated with dynorphin
1) Confidence 0.05 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.34
Accordingly, DREAM interacts with the PDN promoter downstream regulatory element (DRE) under low calcium (<100 nM) conditions, inhibiting PDN transcription in beta-cells.
Transcription (transcription) of PDN
2) Confidence 0.04 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.19

General Comments

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