INT135527

From wiki-pain
Revision as of 09:28, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 6.72
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T-cell 16
lymphocytes 6
macrophage 2
leukocytes 2
nerves 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 180 99.12 Very High Very High Very High
tolerance 12 86.56 High High
Inflammation 190 86.48 High High
Spinal cord 3 82.72 Quite High
Neuropathic pain 3 75.00 Quite High
chemokine 29 71.28 Quite High
Lasting pain 1 69.76 Quite High
Angina 4 50.00 Quite Low
qutenza 3 50.00 Quite Low
palliative 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 282 100.00 Very High Very High Very High
Hypersensitivity 64 99.30 Very High Very High Very High
Sezary Syndrome 14 96.84 Very High Very High Very High
Hypersensitivity Pneumonitis 70 95.84 Very High Very High Very High
Immunization 45 94.68 High High
Malignant Neoplastic Disease 17 94.32 High High
Lymphatic System Cancer 12 90.76 High High
Asthma 251 90.04 High High
INFLAMMATION 200 86.48 High High
Shock 1 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, CD4 KO mice displayed significantly decreased mechanical hypersensitivity after day 7 of L5Tx, and adoptive transfer of CD4(+) leukocytes reversed this effect.
Negative_regulation (reversed) of Gene_expression (transfer) of CD4 in leukocytes associated with hypersensitivity
1) Confidence 0.43 Published 2008 Journal Eur. J. Immunol. Section Abstract Doc Link 18196515 Disease Relevance 0.38 Pain Relevance 0.40
Capsaicin-induced depletion of nociceptive afferent nerves prior to CD4(+)CD25(-) T-cell transfer completely inhibited the development of colitis.
Negative_regulation (depletion) of Gene_expression (transfer) of CD4 in nerves
2) Confidence 0.38 Published 2009 Journal Inflamm. Bowel Dis. Section Body Doc Link 19326358 Disease Relevance 0.07 Pain Relevance 0
Alternatively, T cells were depleted using anti-Thy1 (13.4.6), anti-CD4 (RL172), and anti-CD8 (3.168.8) followed by lysis using rabbit complement (Cedarlane Laboratories Limited; Hornby, Canada).
Negative_regulation (depleted) of Gene_expression (using) of CD4 in T cells
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.13 Pain Relevance 0.04
In addition, the ability of D. andersoni infestation to program specific CD4 T cell expression of IL-4 was significantly reduced during the second infestation.
Negative_regulation (reduced) of Gene_expression (expression) of CD4 in T cell
4) Confidence 0.36 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.12 Pain Relevance 0
Therefore, CD8:CD4 T cell ratio was reduced in BALF of Fc?
Negative_regulation (reduced) of Gene_expression (ratio) of CD4 in T cell
5) Confidence 0.34 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.62 Pain Relevance 0.03
CONCLUSIONS: The findings of this ex vivo study show that CD4(+)CD28null T-cell expansion in patients with UA may be reduced by selective TNF-alpha blockade.
Negative_regulation (reduced) of Gene_expression (expansion) of CD4 in T-cell
6) Confidence 0.34 Published 2006 Journal Circulation Section Body Doc Link 16682617 Disease Relevance 0.11 Pain Relevance 0
The naive CD4+ subset (CD45RA+, CD44?)
Negative_regulation (naive) of Gene_expression (subset) of CD4
7) Confidence 0.33 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.16 Pain Relevance 0.09
RAE and CsA groups treated with OVA resulted in further significant reductions in CD4+/CD8?
Negative_regulation (reductions) of Gene_expression (/) of CD4
8) Confidence 0.33 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.23 Pain Relevance 0.06
Immuno-magnetic depletion of CD4+ and CD8+ lymphocytes
Negative_regulation (depletion) of Gene_expression (lymphocytes) of CD4 in lymphocytes
9) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.05 Pain Relevance 0
Nasal vaccination with N SRS followed by RSV challenge results in the presence of activated CD4+ and CD8+ lymphocytes in airways
Negative_regulation (airways) of Gene_expression (presence) of CD4 in lymphocytes associated with respiratory syncytial virus
10) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.33 Pain Relevance 0.08
Nasal vaccination with N SRS followed by RSV challenge results in the presence of activated CD4+ and CD8+ lymphocytes in airways
Negative_regulation (followed) of Gene_expression (presence) of CD4 in lymphocytes associated with respiratory syncytial virus
11) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.33 Pain Relevance 0.08
Patients with SS can have detectable levels of the leukemic T cells (Sezary cells) in their circulation, and the immunophenotype of these cells is often characterized by the expression of CD4 and absence of CD7 [20, 21].
Negative_regulation (absence) of Gene_expression (expression) of CD4 in T cells associated with sezary syndrome
12) Confidence 0.29 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC3004392 Disease Relevance 1.93 Pain Relevance 0
In vivo depletion of CD4+ CD25+ population
Negative_regulation (depletion) of Gene_expression (population) of CD4
13) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.54 Pain Relevance 0
The blood profile showed reduced CD4+ T-cell levels in heterozygous animals, which are significantly decreased only in females.
Negative_regulation (decreased) of Gene_expression (levels) of CD4 in T-cell
14) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.06 Pain Relevance 0
The blood profile showed reduced CD4+ T-cell levels in heterozygous animals, which are significantly decreased only in females.
Negative_regulation (reduced) of Gene_expression (levels) of CD4 in T-cell
15) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.06 Pain Relevance 0
In contrast to the typical cytokine profiles secreted by T helper cells these iNKT cells, which also may express CD4, are capable of producing large amounts of IL-4, IL-13, and IFN-?
Spec (may) Negative_regulation (may) of Gene_expression (express) of CD4 associated with cytokine
16) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.72 Pain Relevance 0.14
Komatsu et al. even reported that after adoptive transfer of natural CD4+Foxp3+ T cells into lymphopenic or lymphoreplete recipients, a minor fraction enriched within the CD25(?)
Negative_regulation (enriched) of Gene_expression (transfer) of CD4 in T cells
17) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.53 Pain Relevance 0.07
We therefore examined PMA-induced downregulation of exogenously expressed CD4, which was readily radiolabeled and immunoprecipitated using a monoclonal anti-CD4 (Leu3a) antibody.
Spec (examined) Negative_regulation (downregulation) of Gene_expression (expressed) of CD4
18) Confidence 0.23 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.20 Pain Relevance 0
Salp15 inhibits CD4+ T cells activation as well as IL-2 production [9], which can down-regulate Th1 response and therefore macrophage activity.
Negative_regulation (inhibits) of Gene_expression (activation) of CD4 in macrophage
19) Confidence 0.06 Published 2009 Journal Veterinary Research Section Body Doc Link PMC2701186 Disease Relevance 0.15 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox