INT135715

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.70
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
endothelial cells 2
smooth muscle 2
endothelium 2
lung 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 19 79.44 Quite High
agonist 22 77.12 Quite High
Calcitonin gene-related peptide 39 75.52 Quite High
qutenza 14 75.36 Quite High
Potency 3 70.96 Quite High
antagonist 50 56.08 Quite High
local anesthetic 7 50.00 Quite Low
Neurotransmitter 4 28.28 Quite Low
chemokine 3 19.72 Low Low
adenocard 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 132 96.76 Very High Very High Very High
Increased Venous Pressure Under Development 8 95.16 Very High Very High Very High
Renal Disease 8 90.32 High High
Myocardial Infarction 21 89.96 High High
Natriuresis 8 85.12 High High
Stress 5 72.20 Quite High
Pressure And Volume Under Development 9 65.52 Quite High
Acute Decompensated Heart Failure (ADHF) 23 63.20 Quite High
Syndrome 48 57.20 Quite High
Apoptosis 3 52.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of Rh-ET-1 (16 nM) to smooth muscle (Fig. 6D) was reduced by BQ788 (1 µM; Fig. 6E) and was prevented by presence of either ET-1 (16 nM) or of both BQ788 (1 µM) and BQ123 (1 µM)[2] indicating selective binding to ETA- and ETB-receptors.
Negative_regulation (prevented) of Localization (presence) of ET-1 in smooth muscle
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.45
CONCLUSION: Bupivacaine and ropivacaine attenuated N-formyl-L-leucine-methionyl-L-phenylalanine-induced PAP, reduced lung edema, and diminished ET-1 release.
Negative_regulation (diminished) of Localization (release) of ET-1 in lung
2) Confidence 0.41 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690261 Disease Relevance 0 Pain Relevance 0
Although the mechanisms of ET-1 elevation during diabetes are relatively unknown, several research groups speculated that this increase could be due to an abnormal production by the affected endothelium [31] or lack of suppression of ET-1 release secondary to attenuated endothelium-derived relaxing factor production [32].
Negative_regulation (suppression) of Localization (release) of ET-1 in endothelium associated with diabetes mellitus
3) Confidence 0.37 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.76 Pain Relevance 0.08
RESULTS: Pretreatment with LAs significantly reduced the FMLP-induced PAP increase (treatment group v sham group: 0.5 to 5 mm Hg v 8 mm Hg; P < .05) and the release of endothelin-1 (2.4 v 5 fmol/mL).
Negative_regulation (reduced) of Localization (release) of endothelin-1
4) Confidence 0.17 Published 2006 Journal Reg Anesth Pain Med Section Body Doc Link 16701192 Disease Relevance 0 Pain Relevance 0
Whereas AII stimulates the release of ET 1, NO inhibits ET 1 release from endothelial cells.
Negative_regulation (inhibits) of Localization (release) of ET 1 in endothelial cells
5) Confidence 0.04 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 0.94 Pain Relevance 0.03

General Comments

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