INT135744

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.08
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Id1) cytoplasm (Id1)
Anatomy Link Frequency
middle ear 2
Id1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 6 100.00 Very High Very High Very High
Opioid 15 99.84 Very High Very High Very High
Central nervous system 3 93.24 High High
Endogenous opioid 3 87.52 High High
Hippocampus 6 85.60 High High
antagonist 5 85.04 High High
Inflammation 222 83.00 Quite High
cytokine 126 81.00 Quite High
Inflammatory mediators 48 5.00 Very Low Very Low Very Low
chemokine 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 28 98.68 Very High Very High Very High
Metaplasia 8 97.24 Very High Very High Very High
Cholesteatoma 96 97.12 Very High Very High Very High
Otitis Media 268 85.24 High High
INFLAMMATION 288 83.00 Quite High
Otitis 4 76.44 Quite High
Bacterial Infection 8 53.40 Quite High
Hyperplasia 8 51.44 Quite High
Cancer 8 46.40 Quite Low
Otitis Media With Effusion 184 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest a requirement for Id1 in opioid-induced oligodendrogenesis in cultured AHPs possibly acting on opioid-responsive AHPs expressing the proneural transcriptional activator Mash1.
Positive_regulation (requirement) of Id1 associated with opioid
1) Confidence 0.49 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16706836 Disease Relevance 0 Pain Relevance 0.52
Furthermore, beta-endorphin increased the levels of Id1, but not Id3, mRNA on the arrays.
Positive_regulation (levels) of Id1
2) Confidence 0.49 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16706836 Disease Relevance 0 Pain Relevance 0.49
Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors.
Positive_regulation (Requirement) of Id1 associated with narcan and opioid
3) Confidence 0.42 Published 2006 Journal Eur. J. Neurosci. Section Title Doc Link 16706836 Disease Relevance 0 Pain Relevance 0.45
First, Id1 is upregulated in the rat middle ear mucosa following the infection with penumococcus (39).
Positive_regulation (upregulated) of Id1 in middle ear associated with infection
4) Confidence 0.09 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.57 Pain Relevance 0.29
Second, upregulation of Id1 results in thickening of the middle ear mucosa with epithelial cell metaplasia.
Positive_regulation (upregulation) of Id1 in middle ear associated with metaplasia
5) Confidence 0.09 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.51 Pain Relevance 0.27

General Comments

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