INT135866

Context Info Confidence 0.12 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 2.43

transport (Chrne) plasma membrane (Chrne)

Anatomy Link Frequency medulla 3 pons 1 Chrne (Mus musculus)

Pain Link Frequency Relevance Heat medulla 2 100.00 antagonist 16 94.00 antinociception 8 91.12 tail-flick 2 89.60 agonist 16 86.80 Kappa opioid receptor 4 79.72 opioid receptor 12 78.08 mu opioid receptor 2 73.28

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TAN-821 stimulated binding of the non-hydrolyzable guanosine 5'-triphosphate analogue, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via activation of the epsilon receptor.

Positive_regulation (stimulated) of Positive_regulation (activation) of epsilon receptor in medulla associated with medulla

1) Confidence 0.12 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 16719773 Disease Relevance 0 Pain Relevance 1.22

TAN-821 stimulated binding of the non-hydrolyzable guanosine 5'-triphosphate analogue, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via activation of the epsilon receptor.

Positive_regulation (stimulated) of in pons Positive_regulation (activation) of epsilon receptor in medulla associated with medulla

2) Confidence 0.04 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 16719773 Disease Relevance 0 Pain Relevance 1.22

General Comments

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