INT135891

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0.33

plasma membrane (S1pr1) protein complex (Prps1) kinase activity (Prps1) signal transducer activity (S1pr1)

Anatomy Link Frequency dorsal root ganglion 1 S1pr1 (Rattus norvegicus) Prps1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dorsal root ganglion 1 98.72 Inflammation 2 77.28 tetrodotoxin 1 73.60 Action potential 3 59.76 qutenza 1 53.80 Inflammatory response 1 44.08

Disease Link Frequency Relevance Heat Ganglion Cysts 1 98.72 INFLAMMATION 3 50.28 Nociception 1 48.48 Hypersensitivity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results and our finding that the mRNAs for S1PRs are expressed in both the intact dorsal root ganglion and cultures of adult sensory neurons supports the notion that S1P acts on S1PRs linked to G proteins.

S1P Regulation (acts) of S1PRs in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion

1) Confidence 0.01 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16723416 Disease Relevance 0.15 Pain Relevance 0.33

General Comments

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