INT135920

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.57
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRY) nucleus (SRY) DNA binding (SRY)
transcription factor binding (SRY) cytoplasm (SRY)
SRY (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 72 100.00 Very High Very High Very High
Morphine 38 99.48 Very High Very High Very High
Inflammation 4 94.84 High High
Opioid 42 94.56 High High
cytokine 4 92.80 High High
Inflammatory response 2 91.96 High High
peripheral neuropathy 5 91.44 High High
Pain 54 87.96 High High
GABAergic 1 80.76 Quite High
Serotonin 1 73.00 Quite High
Disease Link Frequency Relevance Heat
Depression 73 100.00 Very High Very High Very High
Congenital Anomalies 6 99.28 Very High Very High Very High
Anaemia 5 98.92 Very High Very High Very High
INFLAMMATION 9 94.84 High High
Adverse Drug Reaction 20 93.68 High High
Lipodystrophy 20 93.32 High High
Peripheral Neuropathy 5 91.44 High High
Spontaneous Fractures 5 89.64 High High
Pancreatitis 5 89.36 High High
Affective Disorder 1 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is assumed that drug interaction for TDF-FTC is the same when administered combined or dosed alone as TDF or FTC.
TDF Binding (interaction) of
1) Confidence 0.45 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387297 Disease Relevance 0.35 Pain Relevance 0
TDF was also associated with significantly better overall WOMAC scores and pain scores.
TDF Binding (associated) of
2) Confidence 0.41 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16729276 Disease Relevance 0.11 Pain Relevance 0
Compared with ZDV, TDF is associated with a lower frequency of anemia (4% vs 9%, respectively; p = 0.02) (Gallant et al 2006), and compared with D4T, TDF is associated with fewer lipid abnormalities.
TDF Binding (associated) of associated with anaemia and congenital anomalies
3) Confidence 0.33 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387297 Disease Relevance 0.74 Pain Relevance 0
Any medications that reduce renal function may increase concentration of FTC and TDF.
TDF Binding (concentration) of
4) Confidence 0.30 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387297 Disease Relevance 0.28 Pain Relevance 0
Atazanvir should always be ritonavir boosted (atazanavir 300 mg should be boosted with ritonavir 100 mg) when used with TDF.
TDF Binding (used) of
5) Confidence 0.30 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387297 Disease Relevance 0.33 Pain Relevance 0.05
Compared with ZDV, TDF is associated with a lower frequency of anemia (4% vs 9%, respectively; p = 0.02) (Gallant et al 2006), and compared with D4T, TDF is associated with fewer lipid abnormalities.
TDF Binding (associated) of associated with anaemia and congenital anomalies
6) Confidence 0.29 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387297 Disease Relevance 0.69 Pain Relevance 0
g/h (102 mg) for TDF for older patients compared with 116 mg SRM and 54 ?
TDF Binding (compared) of associated with morphine
7) Confidence 0.28 Published 2007 Journal BMC Med Section Body Doc Link PMC2242794 Disease Relevance 0.17 Pain Relevance 0.94
However, TDF is associated with significantly less constipation rate than that of with SRM.


TDF Binding (associated) of
8) Confidence 0.05 Published 2008 Journal Agri Section Body Doc Link 19085178 Disease Relevance 0 Pain Relevance 0
This study has demonstrated a significant association between severe depression and important dietary intake such as TDF and carbohydrates.
TDF Binding (association) of associated with depression
9) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2994859 Disease Relevance 0.90 Pain Relevance 0.47

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