INT135973

Context Info Confidence 0.06 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.17

cytoplasm (Dpys, Nos2) cytosol (Dpys, Nos2) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (Dpys) peroxisome (Nos2) intracellular (Nos2) extracellular space (Nos2)

Anatomy Link Frequency macrophages 2 Dpys (Mus musculus) Nos2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 4 96.12 qutenza 2 65.32

Disease Link Frequency Relevance Heat INFLAMMATION 4 96.12 Disease 2 52.40

Sentences Mentioned In

Key:

Protein

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Anatomy

Negation

Speculation

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Taken together, these results show that ZTX42 and [6]-DHP suppress NO production in murine macrophages by partially inhibiting iNOS enzymatic activity and reducing iNOS protein production, via attenuation of NF-kappaB-mediated iNOS gene expression, providing a rationale for the anti-inflammatory activity reported for this class of compounds.

DHP Negative_regulation (reducing) of Gene_expression (production) of iNOS in macrophages associated with inflammation

1) Confidence 0.06 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.26 Pain Relevance 0.17

General Comments

This test has worked.