INT136141

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp) extracellular region (Agrp) oxidoreductase activity (Hsd11b1)
Golgi apparatus (Agrp) endoplasmic reticulum (Hsd11b1) lipid metabolic process (Hsd11b1)
Anatomy Link Frequency
brain 2
Hsd11b1 (Mus musculus)
Agrp (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 100.00 Very High Very High Very High
narcan 1 95.20 Very High Very High Very High
antagonist 1 94.84 High High
MU agonist 1 88.96 High High
Endogenous opioid 1 86.84 High High
cocaine 1 44.96 Quite Low
Disease Link Frequency Relevance Heat
Hyperphagia 5 75.00 Quite High
Metabolic Disorder 1 34.12 Quite Low
Metabolic Syndrome 1 31.24 Quite Low
Obesity 1 29.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that 11 beta-HSD1 in brain plays a role in the adaptive restraint of excess fat intake, in part by increasing inhibitory opioid tone on AGRP expression in the arcuate nucleus.
beta-HSD1 Positive_regulation (increasing) of Gene_expression (expression) of AGRP in brain associated with opioid
1) Confidence 0.64 Published 2006 Journal Endocrinology Section Abstract Doc Link 16763061 Disease Relevance 0.20 Pain Relevance 0.47

General Comments

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