INT136153

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 2.71
Pain Relevance 6.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
astrocyte 2
sciatic nerve 1
spinal cord 1
paw 1
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 324 100.00 Very High Very High Very High
Sciatic nerve 18 100.00 Very High Very High Very High
Inflammation 6 99.54 Very High Very High Very High
Morphine 17 99.42 Very High Very High Very High
Pain 68 99.24 Very High Very High Very High
gABA 10 99.24 Very High Very High Very High
antinociception 10 98.82 Very High Very High Very High
Spinal cord 52 98.76 Very High Very High Very High
Thermal hyperalgesia 5 98.74 Very High Very High Very High
Antinociceptive 13 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thyroid Disease 6 99.92 Very High Very High Very High
INFLAMMATION 8 99.54 Very High Very High Very High
Pain 86 99.24 Very High Very High Very High
Hyperalgesia 5 98.74 Very High Very High Very High
Nociception 27 98.28 Very High Very High Very High
Nervous System Injury 34 88.76 High High
Targeted Disruption 1 87.64 High High
Injury 6 81.40 Quite High
Drug Induced Neurotoxicity 1 79.92 Quite High
Cretinism 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute amitriptyline treatment potentiated morphine's antinociceptive effect, with a 5.3-fold leftward shift of morphine's dose-response curve in morphine-tolerant rats, and this was associated with GLAST and GLT-1 trafficking onto the cell surface.
GLAST Binding (associated) of associated with antinociceptive, endep and morphine
1) Confidence 0.40 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.82
However, the total amount of GLT-1 and GLAST one day after ligation did not change.
GLAST Binding (ligation) of
2) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.23 Pain Relevance 0.14
However, it did not influence thermal hyperalgesia in the zymosan-induced paw inflammation model indicating that GLAST is associated with spontaneous rather than inflammatory nociception.
GLAST Binding (associated) of in paw associated with nociception, inflammation and thermal hyperalgesia
3) Confidence 0.31 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.81 Pain Relevance 0.56
The results of this study demonstrate plasticity not only in the expression levels but also in the cellular localization of the glutamate transporters GLT-1 and GLAST following partial sciatic nerve ligation.
GLAST Spec (partial) Binding (ligation) of in sciatic nerve associated with glutamate and sciatic nerve
4) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.12 Pain Relevance 0.25
Moreover, we verified the immunocontent of astrocyte glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) as well as activation of mitogen-activated protein kinases (MAPKs) in hypothyroid rats.
glutamate transporter-1 Binding (immunocontent) of in astrocyte associated with glutamate
5) Confidence 0.23 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.18
Results showed that hypothyroidism is associated with decreased GLAST and GLT-1 immunocontent.
GLAST Binding (associated) of associated with thyroid disease
6) Confidence 0.23 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.29 Pain Relevance 0.25
Moreover, we verified the immunocontent of astrocyte glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) as well as activation of mitogen-activated protein kinases (MAPKs) in hypothyroid rats.
GLAST Binding (immunocontent) of in astrocyte associated with glutamate
7) Confidence 0.23 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.18
Finally, glutamate transporter inhibitors might produce antinociception in pathological pain by the mechanism of blocking inverse operation of the glutamate transporter.
glutamate transporter Spec (might) Binding (operation) of associated with pain, antinociception and glutamate
8) Confidence 0.22 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.25 Pain Relevance 1.22
Do the increased glutamate levels caused by glutamate transporter inhibition lead to increased GABA in the spinal cord?
glutamate transporter Neg (inhibition) Binding (inhibition) of in spinal cord associated with gaba, glutamate and spinal cord
9) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.40 Pain Relevance 1.40

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