INT136251

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 4 98.98 Very High Very High Very High
Nucleus accumbens 7 96.36 Very High Very High Very High
Morphine 7 92.40 High High
narcan 5 89.12 High High
withdrawal 5 85.72 High High
agonist 2 79.56 Quite High
Dopamine 2 75.00 Quite High
opiate 1 68.64 Quite High
Glutamate receptor 1 63.48 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 2 71.04 Quite High
Substance Withdrawal Syndrome 1 5.00 Very Low Very Low Very Low
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, they suggest a dependence-associated shift in the molecular mechanisms that regulate the consequences of D1 receptor stimulation, favoring activation of GluR1 rather than CREB.
Regulation (regulate) of Positive_regulation (activation) of GluR1 associated with addiction
1) Confidence 0.44 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16775132 Disease Relevance 0.07 Pain Relevance 1.46

General Comments

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