INT136271

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.44
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (PNN) nucleolus (PNN) structural molecule activity (PNN)
plasma membrane (PNN) nucleus (PNN) DNA binding (PNN)
Anatomy Link Frequency
bowel 1
PNN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 38 97.80 Very High Very High Very High
headache 39 92.08 High High
Potency 10 89.20 High High
withdrawal 21 85.72 High High
nud 21 67.28 Quite High
anticonvulsant 7 55.12 Quite High
carbamazepine 7 50.88 Quite High
Bioavailability 23 47.96 Quite Low
spastic colon 2 35.68 Quite Low
antagonist 4 21.44 Low Low
Disease Link Frequency Relevance Heat
Renal Disease 7 99.88 Very High Very High Very High
Premenstrual Syndrome 147 99.44 Very High Very High Very High
Keloid Scars 2 99.36 Very High Very High Very High
Acne 252 99.08 Very High Very High Very High
Erythema 2 98.16 Very High Very High Very High
INFLAMMATION 36 97.80 Very High Very High Very High
Inflammatory Bowel Disease 9 95.80 Very High Very High Very High
Polycystic Ovary Syndrome 28 94.80 High High
Headache 41 92.08 High High
Pressure And Volume Under Development 48 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At present, DRSP is only available in 2 OC preparations combined with EE (30 ?
Gene_expression (available) of DRSP
1) Confidence 0.63 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971705 Disease Relevance 1.10 Pain Relevance 0.21
Additionally, no drug interactions were noted between DRSP and EE that would interfere with the progestogenic or antimineralocorticoid activity of DRSP.16
Neg (no) Gene_expression (noted) of DRSP
2) Confidence 0.55 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971705 Disease Relevance 0.08 Pain Relevance 0.12
g (3 mg DRSP/20 ?
Gene_expression (/) of DRSP
3) Confidence 0.27 Published 2009 Journal Patient Prefer Adherence Section Abstract Doc Link PMC2778416 Disease Relevance 0.05 Pain Relevance 0
Two multicenter, double-blind, randomized, placebo-controlled studies on PMDD treatment efficacy of 3 mg DRSP/20 ?
Gene_expression (/) of DRSP associated with premenstrual syndrome
4) Confidence 0.27 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.52 Pain Relevance 0.10
Two double-blind, randomized, placebo-controlled multicenter trials using this OCP were conducted.2 In these trials subjects with moderate acne vulgaris (minimal of 40 facial lesions) received 3 mg DRSP/20 ?
Gene_expression (/) of DRSP associated with acne
5) Confidence 0.27 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.82 Pain Relevance 0.12
Further studies on the 3 mg DRSP/20 ?
Gene_expression (/) of DRSP
6) Confidence 0.27 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.92 Pain Relevance 0.03
g (3 mg DRSP/20 ?
Gene_expression (/) of DRSP
7) Confidence 0.27 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 1.21 Pain Relevance 0.19
In women with renal dysfunction, the DRSP levels are approximately 37% higher.



Gene_expression (levels) of DRSP associated with renal disease
8) Confidence 0.27 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.10 Pain Relevance 0
Introduction to the 3 mg DRSP/20 ?
Gene_expression (Introduction) of DRSP
9) Confidence 0.27 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0 Pain Relevance 0
Calprotectin is an abundant neutrophil protein found in both plasma and stool that is markedly elevated in infectious and inflammatory conditions, including inflammatory bowel disease (IBD).
Gene_expression (found) of neutrophil protein in bowel associated with inflammatory bowel disease and inflammation
10) Confidence 0.01 Published 2006 Journal Inflamm. Bowel Dis. Section Abstract Doc Link 16775498 Disease Relevance 0.62 Pain Relevance 0.24

General Comments

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