INT136682

Context Info Confidence 0.49 First Reported 2006 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 3.16 Pain Relevance 0.57

plasma membrane (BRAF, MC1R) pigmentation (MC1R) cytosol (BRAF) nucleus (BRAF) signal transducer activity (MC1R) cytoplasm (BRAF)

Anatomy Link Frequency germline 1 BRAF (Homo sapiens) MC1R (Homo sapiens)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 7 100.00

Disease Link Frequency Relevance Heat Melanoma 27 99.44 Sunburn 5 99.32 Cutaneous Melanoma 6 99.20 Cancer 3 96.72 Nevus 2 91.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In two independent Caucasian populations, we show that MC1R variants are strongly associated with BRAF mutations in non-CSD melanomas.

BRAF Binding (associated) of MC1R associated with melanoma

1) Confidence 0.49 Published 2006 Journal Science Section Abstract Doc Link 16809487 Disease Relevance 0.91 Pain Relevance 0.09

The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: findings from an Australian population.

BRAF Binding (association) of MC1R associated with cutaneous melanoma

2) Confidence 0.06 Published 2010 Journal J. Invest. Dermatol. Section Title Doc Link 19571821 Disease Relevance 1.03 Pain Relevance 0.22

We observed no association between germline MC1R status and somatic BRAF mutations in melanomas from this population.

BRAF Neg (no) Binding (association) of MC1R in germline associated with melanocortin 1 receptor and melanoma

3) Confidence 0.05 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 19571821 Disease Relevance 1.21 Pain Relevance 0.26

General Comments

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