INT136927

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 14.42
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HGS) endosome (HGS) signal transduction (HGS)
cytoplasm (HGS)
Anatomy Link Frequency
pituitary 2
blood 1
Hepatocyte 1
HGS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 97.88 Very High Very High Very High
headache 5 89.56 High High
Angina 3 81.52 Quite High
depression 58 66.88 Quite High
vincristine 1 20.00 Low Low
Pain 21 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Migraine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 296 100.00 Very High Very High Very High
Anaplastic Large Cell Lymphoma 19 100.00 Very High Very High Very High
Death 103 99.92 Very High Very High Very High
Pituitary Cancer 32 99.92 Very High Very High Very High
Adenoma 28 99.88 Very High Very High Very High
Injury 487 98.96 Very High Very High Very High
Mental Disorders 83 98.44 Very High Very High Very High
Metastasis 8 98.32 Very High Very High Very High
Hypertension 25 96.88 Very High Very High Very High
Sclerosis 11 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HGS and GUK1 were significantly over expressed in GH-secreting adenomas, compared with ACTH-secreting adenomas and nonfunctioning tumors, and with PRL-secreting adenomas, respectively.
Gene_expression (expressed) of HGS associated with adenoma and cancer
1) Confidence 0.70 Published 2006 Journal Pituitary Section Abstract Doc Link 16832584 Disease Relevance 1.74 Pain Relevance 0.10
We have also investigated HGS and GUK1 mRNA expressions in a series of 46 pituitary adenomas (18 nonfunctioning, 12 GH-secreting, nine PRL-secreting, and seven ACTH-secreting adenomas).
Spec (investigated) Gene_expression (expressions) of HGS in pituitary associated with adenoma and pituitary cancer
2) Confidence 0.61 Published 2006 Journal Pituitary Section Abstract Doc Link 16832584 Disease Relevance 1.88 Pain Relevance 0.11
HGS and GUK1 mRNA expression were chosen to be validated by quantitative RT-qPCR, however, only GUK1 had the differential expression confirmed between the adenomas and the metastasis of a pituitary carcinoma.
Gene_expression (expression) of HGS in pituitary associated with adenoma, pituitary cancer and metastasis
3) Confidence 0.61 Published 2006 Journal Pituitary Section Abstract Doc Link 16832584 Disease Relevance 1.88 Pain Relevance 0.12
In the Danish surveys the responses were: excellent, good, acceptable, poor, and very poor and in the HRS: excellent, very good, good, fair, and poor.
Gene_expression (excellent) of HRS
4) Confidence 0.54 Published 2010 Journal Eur J Epidemiol Section Body Doc Link PMC2903692 Disease Relevance 0.43 Pain Relevance 0.07
The HRS began in 1992 and the sample has been resurveyed approximately every 2 years since then.
Gene_expression (began) of HRS
5) Confidence 0.54 Published 2010 Journal Eur J Epidemiol Section Body Doc Link PMC2903692 Disease Relevance 0 Pain Relevance 0
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.
Gene_expression (expressed) of HGS in Hepatocyte associated with adenoma
6) Confidence 0.47 Published 2006 Journal Pituitary Section Title Doc Link 16832584 Disease Relevance 1.49 Pain Relevance 0.12
The above equation was then used to obtain the values of activation energy over a range of HRs from 5 to 600°C min?
Gene_expression (range) of HRs
7) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0 Pain Relevance 0
The HRs of 100, 200 and 300°C min?
Gene_expression (The) of HRs
8) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.33 Pain Relevance 0
A smaller flat portion representing complete cell death and the steeper vertical portion representing considerable (>10%) survival for zero hold time in Fig. 5a intersects at 70°C and complete cell death is observed for HRs of 50°C min?
Gene_expression (observed) of HRs associated with death
9) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.81 Pain Relevance 0
This is due to the fact that for HRs above 50°C min?
Gene_expression (for) of HRs
10) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.36 Pain Relevance 0
Based on the E and A values obtained at HRs of 5–600°C min?
Gene_expression (obtained) of HRs
11) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0 Pain Relevance 0
This is due to the fact that for HRs above 50°C min?
Gene_expression (above) of HRs
12) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.36 Pain Relevance 0
Table 1 shows the combinations of proportionality (kp) and derivative (kd) constants used in the feedback loop to achieve different HRs (100, 200, 300 and 525°C min?
Gene_expression (achieve) of HRs
13) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0 Pain Relevance 0
0.001%) was predicted for target PTs of 60–85°C and HRs of 5–600°C min?
Gene_expression (predicted) of HRs
14) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.41 Pain Relevance 0
1 were obtained for HRs of 5–600°C min?
Gene_expression (obtained) of HRs
15) Confidence 0.46 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.45 Pain Relevance 0
We used the Cox regression to calculate the age- and sex-adjusted hazard ratios (HRs) for first hospital admissions due to mental disorders among immigrants from the former Soviet Bloc 25–84 years old, who arrived to Sweden after 1944 and lived in Sweden during 1994–2001.
Gene_expression (regression) of HRs associated with mental disorders
16) Confidence 0.33 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1828724 Disease Relevance 0.24 Pain Relevance 0
Though E12 and E47 (helix-loop-helix transcription factors) are expressed in HRS as expected, the function of these factors are compromised due to the strong expression of their inhibitors, ID2 and ABF1 [9–11].
Gene_expression (expressed) of HRS
17) Confidence 0.14 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2994062 Disease Relevance 0.77 Pain Relevance 0
During the HRS interview, each respondent was asked whether a doctor had ever told them that they had hypertension ('high blood pressure or hypertension?')
Gene_expression (interview) of HRS in blood associated with hypertension
18) Confidence 0.09 Published 2010 Journal Alzheimers Res Ther Section Body Doc Link PMC2919699 Disease Relevance 2.61 Pain Relevance 0.08
We recently described a novel 21 kDa cell surface and cytoplasmic protein expressed by HL and ALCL cell lines, other CD30+ non-Hodgkin lymphoma cell lines, HRS cells in HL clinical biopsies, and the neoplastic cells in biopsies from ALCL and aggressive NHL patients[24].
Gene_expression (expressed) of HRS associated with lymphatic system cancer, anaplastic large cell lymphoma and hodgkin's disease
19) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.65 Pain Relevance 0

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