INT136929

Context Info Confidence 0.48 First Reported 2006 Last Reported 2006 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 3.75 Pain Relevance 0.23

cytosol (HGS) endosome (HGS) signal transduction (HGS) cytoplasm (HGS)

Anatomy Link Frequency pituitary 2 HGS (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 2 97.88 headache 2 73.76

Disease Link Frequency Relevance Heat Pituitary Cancer 16 99.92 Metastasis 4 98.32 Adenoma 14 97.12 Cancer 14 86.08 Headache 2 73.76 Brain Tumor 2 68.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HGS and GUK1 mRNA expression were chosen to be validated by quantitative RT-qPCR, however, only GUK1 had the differential expression confirmed between the adenomas and the metastasis of a pituitary carcinoma.

Transcription (expression) of HGS in pituitary associated with adenoma, pituitary cancer and metastasis

1) Confidence 0.48 Published 2006 Journal Pituitary Section Abstract Doc Link 16832584 Disease Relevance 1.88 Pain Relevance 0.12

We have also investigated HGS and GUK1 mRNA expressions in a series of 46 pituitary adenomas (18 nonfunctioning, 12 GH-secreting, nine PRL-secreting, and seven ACTH-secreting adenomas).

Spec (investigated) Transcription (expressions) of HGS in pituitary associated with adenoma and pituitary cancer

2) Confidence 0.48 Published 2006 Journal Pituitary Section Abstract Doc Link 16832584 Disease Relevance 1.88 Pain Relevance 0.11

General Comments

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