INT13696

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.97
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL3A1) extracellular region (COL3A1)
Anatomy Link Frequency
connective tissue 1
COL3A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 14 99.34 Very High Very High Very High
Osteoarthritis 6 94.28 High High
cINOD 2 92.64 High High
cva 7 72.00 Quite High
imagery 3 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 14 99.34 Very High Very High Very High
Syndrome 23 96.04 Very High Very High Very High
Aneurism 7 94.84 High High
Osteoarthritis 6 94.28 High High
Ehlers-danlos Syndrome 53 92.84 High High
INFLAMMATION 2 92.12 High High
Marfan Syndrome 2 89.04 High High
Ecchymosis 4 85.36 High High
Prolapse 1 75.20 Quite High
Rupture 8 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, when no mutation of the COL3A1 gene has been identified, the possible existence of yet unidentified hereditary disorders of connective tissue causing arterial aneurysms or dissections, and therefore mimicking EDS type IV, should be considered.
Neg (no) Regulation (mutation) of COL3A1 in connective tissue associated with ehlers-danlos syndrome and aneurism
1) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1971255 Disease Relevance 1.44 Pain Relevance 0.07
Immunoregulatory drugs affected the specific T helper function in response to collagen type III but did not change the proliferative responses to collagen type II and III in patients with RA.
Neg (not) Regulation (change) of collagen type II and III associated with rheumatoid arthritis
2) Confidence 0.38 Published 1991 Journal J. Rheumatol. Section Abstract Doc Link 1676752 Disease Relevance 0.80 Pain Relevance 0.49
Fifty-one patients with rheumatoid arthritis (RA) were examined for their immune response potential to human collagen type II and III.
Spec (examined) Regulation (response) of collagen type II and III associated with rheumatoid arthritis
3) Confidence 0.38 Published 1991 Journal J. Rheumatol. Section Abstract Doc Link 1676752 Disease Relevance 0.73 Pain Relevance 0.39

General Comments

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