INT136962

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Context Info
Confidence 0.89
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.12
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
Anatomy Link Frequency
PFC 1
COMT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 119 100.00 Very High Very High Very High
Catecholamine 4 99.96 Very High Very High Very High
Dopamine 14 99.48 Very High Very High Very High
noradrenaline 2 98.64 Very High Very High Very High
Pain 38 97.96 Very High Very High Very High
cannabis 247 83.96 Quite High
opiate 1 69.00 Quite High
alcohol 20 66.28 Quite High
dopamine receptor 2 64.88 Quite High
IPN 6 55.28 Quite High
Disease Link Frequency Relevance Heat
Pain 36 97.96 Very High Very High Very High
Viral Infection 1 81.84 Quite High
Cognitive Disorder 7 76.00 Quite High
Psychosis 61 74.24 Quite High
Hantavirus Infection 2 68.32 Quite High
Schizophrenia 32 61.88 Quite High
Inflammatory Pain 6 55.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 22 50.00 Quite Low
Infection 7 50.00 Quite Low
Nociception 4 42.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One such candidate is catechol-O-methyltransferease (COMT) which is a mammalian enzyme involved in the metabolic degradation of released dopamine, particularly in the PFC [19].
Protein_catabolism (degradation) of COMT in PFC associated with dopamine
1) Confidence 0.89 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.19 Pain Relevance 0.26
Cloning and structural analysis of the human distal COMT promoter
Protein_catabolism (analysis) of COMT associated with catechol-o-methyltransferase
2) Confidence 0.76 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.06 Pain Relevance 0.63
On the genetic aspect, a functional polymorphism of the gene encoding the catechol-O-methyl transferase (COMT) enzyme (which degrades catecholamines such as dopamine, noradrenaline etc.) has been of interest.
Protein_catabolism (degrades) of COMT associated with dopamine, catecholamine and noradrenaline
3) Confidence 0.64 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.38 Pain Relevance 0.54
A single nucleotide polymorphism (SNP) in codon 158 (val(158)met), which affects COMT protein stability, has been associated with the human experience of pain.
Protein_catabolism (stability) of COMT associated with pain and catechol-o-methyltransferase
4) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16837133 Disease Relevance 0.49 Pain Relevance 0.72

General Comments

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