INT136962

Context Info Confidence 0.89 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.12 Pain Relevance 2.14

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT) plasma membrane (COMT) cytoplasm (COMT)

Anatomy Link Frequency PFC 1 COMT (Homo sapiens)

Pain Link Frequency Relevance Heat Catechol-O-methyltransferase 119 100.00 Catecholamine 4 99.96 Dopamine 14 99.48 noradrenaline 2 98.64 Pain 38 97.96 cannabis 247 83.96 opiate 1 69.00 alcohol 20 66.28 dopamine receptor 2 64.88 IPN 6 55.28

Disease Link Frequency Relevance Heat Pain 36 97.96 Viral Infection 1 81.84 Cognitive Disorder 7 76.00 Psychosis 61 74.24 Hantavirus Infection 2 68.32 Schizophrenia 32 61.88 Inflammatory Pain 6 55.28 Acquired Immune Deficiency Syndrome Or Hiv Infection 22 50.00 Infection 7 50.00 Nociception 4 42.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One such candidate is catechol-O-methyltransferease (COMT) which is a mammalian enzyme involved in the metabolic degradation of released dopamine, particularly in the PFC [19].

Protein_catabolism (degradation) of COMT in PFC associated with dopamine

1) Confidence 0.89 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.19 Pain Relevance 0.26

Cloning and structural analysis of the human distal COMT promoter

Protein_catabolism (analysis) of COMT associated with catechol-o-methyltransferase

2) Confidence 0.76 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.06 Pain Relevance 0.63

On the genetic aspect, a functional polymorphism of the gene encoding the catechol-O-methyl transferase (COMT) enzyme (which degrades catecholamines such as dopamine, noradrenaline etc.) has been of interest.

Protein_catabolism (degrades) of COMT associated with dopamine, catecholamine and noradrenaline

3) Confidence 0.64 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.38 Pain Relevance 0.54

A single nucleotide polymorphism (SNP) in codon 158 (val(158)met), which affects COMT protein stability, has been associated with the human experience of pain.

Protein_catabolism (stability) of COMT associated with pain and catechol-o-methyltransferase

4) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16837133 Disease Relevance 0.49 Pain Relevance 0.72

General Comments

This test has worked.