INT137008

Context Info Confidence 0.49 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.51 Pain Relevance 0.30

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2) intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)

Anatomy Link Frequency PSCs 2 SMAD2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 98.60 COX-2 inhibitor 1 85.16 Chronic pancreatitis 2 68.40 Inflammatory response 1 63.12 COX2 1 25.00 ketamine 3 5.00 imagery 2 5.00 anesthesia 1 5.00 fibrosis 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Primary Sclerosing Cholangitis 3 95.84 Hypertrophy 18 77.04 Pancreatitis 2 68.40 INFLAMMATION 1 62.72 Muscular Dystrophy 17 5.00 Targeted Disruption 10 5.00 Hyperplasia 9 5.00 Body Weight 6 5.00 Dilated Cardiomyopathy 5 5.00 Coronary Heart Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Adenovirus-mediated expression of dominant negative Smad2/3 inhibited the increase in expression of COX-2, alpha-SMA, and collagen-1 mediated by TGF-beta1 in activated PSCs.

Positive_regulation (Adenovirus-mediated) of Gene_expression (expression) of Smad2 in PSCs

1) Confidence 0.49 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.43 Pain Relevance 0.30

In C57 Bl/6 mice overexpressing dnMstat there was a decrease in the levels of phosphorylated Smad 2/3 as was seen in C2C12 cells incubated with anti-myostatin antibody [3].

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Smad 2

2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.08 Pain Relevance 0

General Comments

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