INT137051

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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.88
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
spinal 2
cortex 2
hippocampus 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 61 100.00 Very High Very High Very High
nMDA receptor 56 100.00 Very High Very High Very High
Hippocampus 26 97.84 Very High Very High Very High
Glutamate receptor 8 95.72 Very High Very High Very High
Dorsal horn 3 89.48 High High
superficial lamina 1 88.72 High High
Hyperalgesia 18 85.12 High High
Spinal cord 5 81.20 Quite High
interneuron 1 75.20 Quite High
antinociception 5 72.88 Quite High
Disease Link Frequency Relevance Heat
Nociception 26 92.04 High High
Injury 19 86.32 High High
Hyperalgesia 18 85.12 High High
Anxiety Disorder 2 66.96 Quite High
Depression 79 50.00 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Amnesia 3 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in this study, spinal NMDA antagonist and AMPA antagonist reduced not only the phase 1 response but also the phase 2 response.
Negative_regulation (reduced) of Gene_expression (antagonist) of AMPA in spinal associated with antagonist
1) Confidence 0.18 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808611 Disease Relevance 0.81 Pain Relevance 1.09
The expression of NR2B (NMDA receptor) and GluR1 (AMPA receptor) subunits was significantly reduced in the TCDD-exposed F1 generation animals compared to vehicle controls.
Negative_regulation (reduced) of Gene_expression (expression) of AMPA associated with nmda receptor
2) Confidence 0.07 Published 2006 Journal Neurotoxicology Section Abstract Doc Link 16839606 Disease Relevance 0 Pain Relevance 0.21
The results indicate that gestational TCDD exposure results in cortical deficits that are paralled by diminished expression of certain NMDA and AMPA receptor subunits at a time when synapses are being formed for the first time in cortex.
Negative_regulation (diminished) of Gene_expression (expression) of AMPA in cortex
3) Confidence 0.06 Published 2006 Journal Neurotoxicology Section Abstract Doc Link 16839606 Disease Relevance 0 Pain Relevance 0.19
Here we show that consolidation of inhibitory avoidance (IA) LTM entails mTOR activation in the dorsal hippocampus at the moment of and 3 h after training and is associated with a rapid and rapamycin-sensitive increase in AMPA receptor GluR1 subunit expression, which was also blocked by intra-hippocampal delivery of GluR1 antisense oligonucleotides (ASO).
Negative_regulation (blocked) of Gene_expression (expression) of AMPA receptor in hippocampus associated with hippocampus
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.05
After obtaining a baseline of equal AMPA responses, the concentration of CNQX was raised to 10 ?
Negative_regulation (baseline) of Gene_expression (responses) of AMPA
5) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC517399 Disease Relevance 0 Pain Relevance 0.07

General Comments

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