INT137082

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC2) ATPase activity (ABCC2) plasma membrane (ABCC2)
transmembrane transport (ABCC2)
Anatomy Link Frequency
enterocyte 1
bile 1
ABCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 70 100.00 Very High Very High Very High
cINOD 3 90.04 High High
diclofenac 1 80.20 Quite High
fibrosis 14 76.64 Quite High
Kinase C 1 66.40 Quite High
agonist 5 24.80 Low Low
Inflammation 23 5.00 Very Low Very Low Very Low
pruritus 14 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 15 93.92 High High
Gallstones 23 89.68 High High
Biliary Liver Cirrhosis 246 89.00 High High
INFLAMMATION 24 79.24 Quite High
Fibrosis 16 76.64 Quite High
Apoptosis 27 73.76 Quite High
Diarrhoea 1 66.48 Quite High
Liver Disease 23 51.84 Quite High
Cirrhosis 16 45.56 Quite Low
Increased Venous Pressure Under Development 2 24.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Observations from clinical and experimental studies have defined key events in the pathogenesis of these drugs, including roles for multidrug resistance-associated protein 2 (MRP2) and other transporters in biliary secretion and adduction of enterocyte proteins by reactive acyl glucuronide metabolites as a likely mechanism for intestinal injury.
Regulation (roles) of MRP2 in enterocyte associated with injury
1) Confidence 0.16 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16842856 Disease Relevance 0.65 Pain Relevance 0.36
This effect of UDCA seems to be mediated by posttranscriptional rather than transcriptional mechanisms, as mRNA levels of key transporters like the conjugate export pump, ABCC2/MRP2, and the bile salt export pump, ABCB11/BSEP, are not affected by UDCA in man.
Neg (not) Regulation (affected) of MRP2 in bile associated with bile
2) Confidence 0.07 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.46 Pain Relevance 0.49

General Comments

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