INT137179

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.73
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL9) extracellular space (CXCL9) extracellular region (CXCL9)
cell-cell signaling (CXCL9)
Anatomy Link Frequency
myocardium 1
synovial fluids 1
joint 1
endothelial cells 1
umbilical vein 1
CXCL9 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 308 100.00 Very High Very High Very High
rheumatoid arthritis 353 99.84 Very High Very High Very High
Arthritis 20 99.40 Very High Very High Very High
cytokine 94 99.12 Very High Very High Very High
spinal inflammation 4 98.72 Very High Very High Very High
Inflammation 103 96.32 Very High Very High Very High
Etanercept 5 91.92 High High
antagonist 6 82.64 Quite High
agonist 8 77.12 Quite High
Osteoarthritis 19 60.56 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 353 99.84 Very High Very High Very High
Arthritis 16 99.40 Very High Very High Very High
Viral Infection 4 99.28 Very High Very High Very High
Seronegative Spondarthritis 4 99.18 Very High Very High Very High
Low Back Pain 4 98.72 Very High Very High Very High
Spondylarthropathies 4 98.18 Very High Very High Very High
Necrosis 9 97.88 Very High Very High Very High
Cancer 8 97.70 Very High Very High Very High
Cardiomyopathy 32 97.60 Very High Very High Very High
Targeted Disruption 5 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, peptidoglycan (PGN), double-stranded (ds) RNA or lipopolysaccharide (LPS) (TLR2, TLR3 or TLR4 ligands, respectively) synergized with interferon-gamma (IFN-gamma) at inducing CXCL9 and CXCL10.
Positive_regulation (inducing) of CXCL9
1) Confidence 0.65 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.31 Pain Relevance 0.27
In synovial fluids of patients with spondylarthropathies (ie ankylosing spondylitis or psoriatic arthritis) or rheumatoid arthritis, significantly enhanced CXCL9, but not CXCL11 levels, were detected compared to concentrations in synovial fluids of patients with metabolic crystal-induced arthritis.
Positive_regulation (enhanced) of CXCL9 in synovial fluids associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, spondylarthropathies and arthritis
2) Confidence 0.65 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.71 Pain Relevance 0.54
The upregulation of CXCL9 in RA synovia is in agreement with the only microarray study of RA synovia, in which this chemokine was also shown to be increased [31].
Positive_regulation (upregulation) of CXCL9 associated with chemokine and rheumatoid arthritis
3) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.20 Pain Relevance 1.00
Of these chemokines, the following showed upregulation: CCL18 (4.5 ± 0.4-fold increase), CXCL9 (3.6 ± 0.1-fold increase), CXCL5 (3.5 ± 0.3-fold increase), and CXCL8 (3.3 ± 0.2-fold increase).
Positive_regulation (upregulation) of CXCL9 associated with chemokine
4) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.30 Pain Relevance 1.07
-inducible T cell-chemoattractant genes CXCL11 (I-TAC) and CXCL9 (MIG) in the myocardium from all three groups of monkeys.
Positive_regulation (inducible) of MIG in myocardium
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009713 Disease Relevance 0.61 Pain Relevance 0.08
TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis.
Positive_regulation (enhanced) of CXCL9 in endothelial cells associated with arthritis and cytokine
6) Confidence 0.47 Published 2006 Journal Lab. Invest. Section Title Doc Link 16847431 Disease Relevance 0.31 Pain Relevance 0.31
In analogy with TLR ligands, tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), in combination with IFN-gamma, synergistically induced CXCL9 and CXCL11 in HMVEC and human fibroblasts, two fundamental cell types delineating the joint cavity.
Positive_regulation (induced) of CXCL9 in joint associated with necrosis and cancer
7) Confidence 0.47 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.56 Pain Relevance 0.43
-inducible chemokines CXCL9 and CXCL10, both ligands for CXCR3, have been found in chronically inflamed synovial tissue [10].
Positive_regulation (inducible) of CXCL9 associated with chemokine
8) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.50 Pain Relevance 0.39
But here IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.
Positive_regulation (induction) of Mig in T lymphocytes associated with inflammation
9) Confidence 0.26 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.59 Pain Relevance 0.27
-independent activation of MIG and IP-10 has been observed in primary human umbilical vein endothelial cells (HUVECs) in response to infection by influenza virus [33].
Neg (independent) Positive_regulation (activation) of MIG in umbilical vein associated with influenza virus infection and infection
10) Confidence 0.19 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 0.75 Pain Relevance 0.36
are able to induce MIG in response to a viral infection in vivo [34].
Positive_regulation (induce) of MIG associated with viral infection
11) Confidence 0.16 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 0.88 Pain Relevance 0.39

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